Actin nucleation: bacteria get in-spired

被引：14

作者：

Quinlan, Margot E. ^{[1
]}

Kerkhoff, Eugen ^{[2
]}

机构：

[1] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94107 USA

[2] Univ Regensburg, Bayer Genomforschungsnetzwerk BayGene, Inst Funkt Genom, D-93053 Regensburg, Germany

来源：

NATURE CELL BIOLOGY | 2008年 / 10卷 / 01期

关键词：

D O I：

10.1038/ncb0108-13

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Spir proteins nucleate actin polymerization by assembling a linear actin oligomer along a cluster of four actin-binding WH2 domains, and this process is enhanced by formins of the Cappuccino family. The discovery of Spir-like proteins in bacteria indicates that pathogens have adopted this mechanism to manipulate the host actin cytoskeleton.

引用

页码：13 / 15

页数：4

共 16 条

[1] Cordon-bleu is an actin nucleation factor and controls neuronal morphology
Ahuja, Rashmi
Pinyol, Roser
Reichenbach, Nicole
Custer, Laura
Klingensmith, John
Kessels, Michael M.
Qualmann, Britta
[J]. CELL, 2007, 131 (02) : 337 - 350
[2] Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly
Chereau, D
Kerff, F
Graceffa, P
Grabarek, Z
Langsetmo, K
Dominguez, R
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (46) : 16644 - 16649
[3] Capu and spire assemble a cytoplasmic actin mesh that maintains microtubule organization in the Drosophila oocyte
Dahlgaard, Katja
Raposo, Alexandre A. S. F.
Niccoli, Teresa
St Johnston, Daniel
[J]. DEVELOPMENTAL CELL, 2007, 13 (04) : 539 - 553
[4] Formin proteins: a domain-based approach
Higgs, HN
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 2005, 30 (06) : 342 - 353
[5] Control of the assembly of ATP- and ADP-actin by formins and profilin
Kovar, DR
Harris, ES
Mahaffy, R
Higgs, HN
Pollard, TD
[J]. CELL, 2006, 124 (02) : 423 - 435
[6] Arp2/3-independent assembly of actin by Vibrio type III effector VopL
Liverman, Amy D. B.
Cheng, Hui-Chun
Trosky, Jennifer E.
Leung, Daisy W.
Yarbrough, Melanie L.
Burdette, Dara L.
Rosen, Michael K.
Orth, Kim
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (43) : 17117 - 17122
[7] CAPPUCCINO AND SPIRE - 2 UNIQUE MATERNAL-EFFECT LOCI REQUIRED FOR BOTH THE ANTEROPOSTERIOR AND DORSOVENTRAL PATTERNS OF THE DROSOPHILA EMBRYO
MANSEAU, LJ
SCHUPBACH, T
[J]. GENES & DEVELOPMENT, 1989, 3 (09) : 1437 - 1452
[8] Regulation of actin filament assembly by Arp2/3 complex and formins
Pollard, Thomas D.
[J]. ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 2007, 36 : 451 - 477
[9] Mechanism of formin-induced nucleation of actin filaments
Pring, M
Evangelista, M
Boone, C
Yang, CS
Zigmond, SH
[J]. BIOCHEMISTRY, 2003, 42 (02) : 486 - 496
[10] Regulatory interactions between two actin nucleators, Spire and Cappuccino
Quinlan, Margot E.
Hilgert, Susanne
Bedrossian, Anaid
Mullins, R. Dyche
Kerkhoff, Eugen
[J]. JOURNAL OF CELL BIOLOGY, 2007, 179 (01) : 117 - 128

← 1 2 →