Formulation of alginate based hydrogel from brown seaweed, Turbinaria conoides for biomedical applications

被引：20

作者：

Kavitha, Naidu ^{[1
]}

Karunya, Thennarasu Padmini ^{[2
]}

Kanchana, Shankar ^{[1
]}

Mohan, Kumar ^{[1
]}

Sivaramakrishnan, Ramachandiran ^{[1
]}

Uthra, Selvaraj ^{[1
]}

Kapilan, Kalimuthu ^{[1
]}

Yuvaraj, Dinakarkumar ^{[2
]}

Arumugam, Muthuvel ^{[1
]}

机构：

[1] Annamalai Univ, Fac Marine Sci, CAS Marine Biol, Parangipettai 608502, Tamil Nadu, India

[2] Vel Tech High Tech Dr Rangarajan Dr Sakunthala En, Dept Biotechnol, Chennai 600062, Tamil Nadu, India

来源：

HELIYON | 2019年 / 5卷 / 12期

关键词：

Materials science; Materials chemistry; Biomedical engineering; Pharmaceutical science; Biotechnology; Hydrogel; Microfilm; Microbead; Wound healing; Drug delivery; Sustained release; FILMS;

D O I：

10.1016/j.heliyon.2019.e02916

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sodium Alginate (SA) is an excellent carrier in various drug delivery systems. In this study, SA was synthesized from brown seaweed, Turbinaria conoides with a yield of 31.3 +/- 0.86%. The analysis of physicochemical properties of extracted alginate (ALG) determined its purity. The structural confirmations of ALG were studied through FTIR, XRD and SEM analysis. Formulation of ALG with collagen (COL) as a wound healing microfilm showed potential anti-inflammatory properties (81.3 +/- 1.77%) and sustained drug release. Likewise, the ALG microbead encapsulated with an anticancer drug, Tamoxifen indicated an in vitro sustained release in the range of 62 +/- 0.70% - 91 +/- 0.56%. The overall swelling behavior of both the hydrogels, microfilm and microbead provides new opportunities for development of natural ALG in this therapeutic era.

引用

页数：10

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