The role of cholinesterases in rat urinary bladder contractility

被引：12

作者：

Nakahara, T ^{[1
]}

Kubota, Y ^{[1
]}

Sakamoto, K ^{[1
]}

Ishii, K ^{[1
]}

机构：

[1] Kitasato Univ, Sch Pharmaceut Sci, Dept Mol Pharmacol, Tokyo 1088641, Japan

来源：

UROLOGICAL RESEARCH | 2003年 / 31卷 / 03期

关键词：

acetylcholine; acetylcholinesterase; butyrylcholinesterase; urinary bladder;

D O I：

10.1007/s00240-003-0326-1

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

This study examines the effects of inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) on acetylcholine (ACh)-induced contraction in rat urinary bladder smooth muscle. Neostigmine, a non-selective ChE inhibitor, caused concentration-dependent contractions in rat urinary bladder strips, whereas tetraisopropylpyrophosphoramide (iso-OMPA; a BuChE inhibitor) failed to affect the resting tone of the preparations. Neostigmine (1 muM) markedly augmented the contractile responses to ACh. Although iso-OMPA (10 muM) also potentiated ACh-induced contraction, the effect was less than that evoked by neostigmine. The activities of AChE in rat urinary bladder strips were significantly (P<0.05) higher than those of BuChE. These results indicated that AChE, rather than BuChE, plays an important role in controlling ACh-induced contractions of rat urinary bladder.

引用

页码：223 / 226

页数：4

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