Evidence for Hypothalamus-Pituitary-Adrenal Axis and Immune Alterations at Prodrome of Psychosis in Males

被引：11

作者：

Karanikas, Evangelos ^{[1
,2
]}

Ntouros, Evangelos ^{[2
]}

Oikononnou, Dimitrios ^{[2
]}

Floros, Georgios ^{[3
]}

Griveas, Loan-Nis ^{[4
]}

Garyfallos, Georgios ^{[3
]}

机构：

[1] Univ Queensland, Sch Med, Rural Clin Sch, 152 West St, Toowoomba, Qld 4350, Australia

[2] Gen Mil Hosp Thessaloniki, Psychiat Dept, Thessaloniki, Greece

[3] Aristotle Univ Thessaloniki, Psychiat Hosp Thessaloniki, Psychiat Dept 2, Thessaloniki, Greece

[4] Gen Mil Hosp Athens, Athens, Greece

来源：

PSYCHIATRY INVESTIGATION | 2017年 / 14卷 / 05期

关键词：

Cortisol; Cytokines; Inflammation; Prodrome; Ultra high risk; INCREASED SERUM INTERLEUKIN-6; RISK MENTAL STATES; SCHIZOPHRENIC-PATIENTS; METAANALYSIS; ASSOCIATION; SYMPTOMS; SYSTEM; NAIVE;

D O I：

10.4306/pi.2017.14.5.703

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

We aimed to investigate the inflammatory substrate in psychosis by evaluating both the Hypothalamus-Pituitary-Adrenal axis function and immune state at prodrome. This involved the recruitment of Ultra High Risk (UHR) of Psychosis subjects, Healthy Controls (HC) and patients with established Schizophrenia (CHRON). Serum cortisol at 3 different times throughout the day was measured. The Dexamethasone Suppression Test was performed plus 12 circulating cytokines were measured. The UHR subjects presented increased IL-4 levels compared with both the HC and CHRON patients. In contrast the UHR differed only from the CHRON group regarding the endocrine parameters. In conclusion, IL-4 appears to play a key role at prodrome.

引用

页码：703 / 707

页数：5

共 22 条

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