Proteomics in uveal melanoma

被引：5
作者：
Heiferman, Michael J. [1 ,2 ]
Mahajan, Vinit B. [2 ,3 ]
Mruthyunjaya, Prithvi [2 ,4 ]
机构：
[1] Univ Illinois, Dept Ophthalmol, Illinois Eye & Ear Infirm, Chicago, IL 60680 USA
[2] Stanford Univ, Byers Eye Inst, Dept Ophthalmol, Palo Alto, CA 94304 USA
[3] Vet Affairs Palo Alto Healthcare Syst, Palo Alto, CA USA
[4] Stanford Univ, Dept Radiat Oncol, Palo Alto, CA 94304 USA
来源：
CURRENT OPINION IN OPHTHALMOLOGY | 2022年 / 33卷 / 03期
关键词：
aqueous humor; biomarker; liquid biopsy; proteomics; uveal melanoma; vitreous; INHIBITORY-ACTIVITY; AQUEOUS-HUMOR; SERUM MARKER; EXPRESSION; IDENTIFICATION; OSTEOPONTIN; METASTASIS; PROTEINS; ACTIVATION; BIOMARKERS;
D O I：
10.1097/ICU.0000000000000835
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Purpose of review This article reviews the latest proteomic research on uveal melanoma. Recent findings Proteomic analysis of uveal melanoma cell lines and tissue specimens has improved our understanding of the pathophysiology of uveal melanoma and helped identify potential prognostic biomarkers. Circulating proteins in patient serum may aid in the surveillance of metastatic disease. The proteomes of aqueous and vitreous biopsy specimens may provide safer biomarkers for metastatic risk and candidate therapeutic targets in uveal melanoma. Proteomic analysis has the potential to benefit patient outcomes by improving diagnosis, prognostication, surveillance, and treatment of uveal melanoma. Summary These recent findings demonstrate that proteomic analysis is an important area of research to better understand the pathophysiology of uveal melanoma and improve the personalized management of our patients.
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收藏
页码：202 / 210
页数：9
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