Conditioned taste aversion: modulation by 5-HT receptor activity and corticosterone

被引：24

作者：

Gorzalka, B ^{[1
]}

Hanson, L ^{[1
]}

Harrington, J ^{[1
]}

Killam, S ^{[1
]}

Campbell-Meiklejohn, D ^{[1
]}

机构：

[1] Univ British Columbia, Dept Psychol, Vancouver, BC V6T 1Z4, Canada

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2003年 / 471卷 / 02期

关键词：

lithium chloride; conditioned taste aversion; nefazodone; corticosterone;

D O I：

10.1016/S0014-2999(03)01790-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Two experiments were designed to elucidate the involvement of the hypothalamic-pituitary-adrenal axis and the 5-hydroxytryptamine (5-HT) system in the acquisition of lithium chloride-conditioned taste aversion. In Experiment 1, rats were administered either vehicle or 50 mg/kg nefazodone daily for 4 weeks. Rats were treated with 22 mg/kg of lithium chloride in order to produce conditioned taste aversion to a sucrose solution. Three days later, nefazodone completely blocked the lithium chloride-conditioned taste aversion. In Experiment 2, the effects of chronic corticosterone administration on lithium chloride-conditioned taste aversion were investigated. Twenty male rats received either corticosterone at a dose of (50 mg/kg) or vehicle injections over a period of 14 consecutive days. Lithium chloride-conditioned taste aversion was potentiated in rats treated with corticosterone. Additionally, corticosterone-treated animals required more trials to reach extinction. These results suggest the involvement of both the 5-HT system and the hypothalamic-pituitary-adrenal axis in lithium chloride-conditioned taste aversion. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：129 / 134

页数：6

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