Cycloartane glycosides from Astragalus stereocalyx Bornm.

被引：25

作者：

Yalcin, Funda Nuray ^{[1
]}

Piacente, Sonia ^{[2
]}

Perrone, Angela ^{[2
]}

Capasso, Anna ^{[2
]}

Duman, Hayri ^{[3
]}

Calis, Ihsan ^{[4
]}

机构：

[1] Hacettepe Univ, Fac Pharm, Dept Pharmacognosy, TR-06100 Ankara, Turkey

[2] Univ Salerno, Dipartimento Sci Farmaceut & Biomed, I-84084 Fisciano, Italy

[3] Gazi Univ, Fac Arts & Sci, Dept Biol, Ankara, Turkey

[4] Near East Univ, Fac Pharm, Dept Pharmacognosy, Nicosia, Cyprus

来源：

PHYTOCHEMISTRY | 2012年 / 73卷

关键词：

Astragalus stereocalyx; Cycloartane saponins; Cycloasgenin C; TRITERPENE GLYCOSIDES; SAPONINS; PLANTS; ROOTS;

D O I：

10.1016/j.phytochem.2011.09.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Six cycloartane-type triterpene glycosides were isolated from Astragalus stereocalyx along with six known cycloartane-type glycosides. Their structures were established by the extensive use of 1D and 2D-NMR experiments along with ESIMS and HRMS analysis. Three compounds are based on an aglycon characterized by the occurrence of an unusual hydroxyl group at position 20, whereas three other compounds are based on cycloasgenin C as aglycon, so far reported from Astragalus spp. All the compounds were tested for their cytotoxic activity against a number of cancer cell lines. One compound exhibited activity versus human cervical cancer (Hela) with an IC50 value 10 mu M. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：119 / 126

页数：8

共 28 条

[1]

Agzamova M.A, 1998, CHEM NAT COMPD, P155

[2]

Aytac Z., 2000, Flora of Turkiye and the East Aegean Islands, V11, P79

[3]

Bedir E, 2000, BIOL PHARM BULL, V23, P834, DOI 10.1248/bpb.23.834

[4] Trojanoside H:: a cycloartane-type glycoside from the aerial parts of Astragalus trojanus [J].

Bedir, E ;

Çalis, I ;

Aquino, R ;

Piacente, S ;

Pizza, C .

PHYTOCHEMISTRY, 1999, 51 (08) :1017-1020

[5]

Bedir E, 2000, CHEM PHARM BULL, V48, P1081

[6] Cycloartane triterpene glycosides from the roots of Astragalus melanophrurius [J].

Calis, I ;

Yuruker, A ;

Tasdemir, D ;

Wright, AD ;

Sticher, O ;

Luo, YD ;

Pezzuto, JM .

PLANTA MEDICA, 1997, 63 (02) :183-186

[7]

Calis I, 1996, ADV EXP MED BIOL, V404, P485

[8]

Çalis I, 2008, Z NATURFORSCH C, V63, P813

[9]

Davis P.H., 1965, FLORA TURKEY E AEGEA, DOI DOI 10.1101/GR.132102

[10]

Davis P.H., 1988, Flora of Turkiye and the East Aegean Islands, V10, P114

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