Paradoxical roles of Foxp3+ T cells during infection:: From regulators to regulators

被引：4

作者：

Belkaid, Yasmine ^{[1
]}

机构：

[1] NIAID, Mucosal Immunol Unit, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

来源：

CELL HOST & MICROBE | 2008年 / 3卷 / 06期

关键词：

D O I：

10.1016/j.chom.2008.05.011

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

T cells expressing the transcription factor Foxp3 have been shown to limit immune responses against microbes. In a recent issue of Science, Lund et al. support the idea that these cells can also coordinate the early entrance of innate cells at the effector site and therefore positively contribute to protective immunity.

引用

页码：341 / 343

页数：3

共 10 条

[1] Regulatory T cells and infection: a dangerous necessity [J].

Belkaid, Yasmine .

NATURE REVIEWS IMMUNOLOGY, 2007, 7 (11) :875-888

[2] Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice [J].

Kim, Jeong M. ;

Rasmussen, Jeffrey P. ;

Rudensky, Alexander Y. .

NATURE IMMUNOLOGY, 2007, 8 (02) :191-197

[3] Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease [J].

Lahl, Katharina ;

Loddenkemper, Christoph ;

Drouin, Cathy ;

Freyer, Jennifer ;

Arnason, Jon ;

Eberl, Gerard ;

Hamann, Alf ;

Wagner, Hermann ;

Huehn, Jochen ;

Sparwasser, Tim .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (01) :57-63

[4] Toll-like receptor 9-mediated recognition of herpes simplex virus-2 by plasmacytoid dendritic cells [J].

Lund, J ;

Sato, A ;

Akira, S ;

Medzhitov, R ;

Iwasaki, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (03) :513-520

[5]

LUND JM, 2008, SCIENCE, V293, P2087

[6] Regulatory T cells in the control of immune pathology [J].

Maloy, KJ ;

Powrie, F .

NATURE IMMUNOLOGY, 2001, 2 (09) :816-822

[7]

Powrie Fiona, 2003, Novartis Found Symp, V252, P92

[8] Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells:: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance [J].

Sakaguchi, S ;

Sakaguchi, N ;

Shimizu, J ;

Yamazaki, S ;

Sakihama, T ;

Itoh, M ;

Kuniyasu, Y ;

Nomura, T ;

Toda, M ;

Takahashi, T .

IMMUNOLOGICAL REVIEWS, 2001, 182 :18-32

[9] A crucial role for plasmacytoid dendritic cells in antiviral protection by CpG ODN-based vaginal microbicide [J].

Shen, Hong ;

Iwasaki, Akiko .

JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (08) :2237-2243

[10] CD4+ CD25+ regulatory T cells control the severity of viral immunoinflammatory lesions [J].

Suvas, S ;

Azkur, AK ;

Kim, BS ;

Kumaraguru, U ;

Rouse, BT .

JOURNAL OF IMMUNOLOGY, 2004, 172 (07) :4123-4132

← 1 →