Anaphylaxis during the first course of high-dose methotrexate: a case report and literature review

被引：7
作者：
Pugi, A. [1 ,2 ]
Benemei, S. [1 ]
Vietri, M. [1 ,2 ]
Tondo, A. [3 ]
Calvani, A. M.
Mugelli, A. [1 ,2 ]
Vannacci, A. [1 ,2 ]
Lapi, F. [1 ,2 ]
机构：
[1] Univ Florence, Dept Preclin & Clin Pharmacol, I-50139 Florence, Italy
[2] Tuscan Reg Ctr Pharmacovigilance, Florence, Italy
[3] Meyer Childrens Hosp, Hematol Oncol Unit, Florence, Italy
来源：
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS | 2012年 / 37卷 / 02期
关键词：
adverse reaction; anaphylaxis; methotrexate; pharmacovigilance; SUCCESSFUL DESENSITIZATION; SYSTEMIC-ANAPHYLAXIS; OSTEOSARCOMA; PATIENT;
D O I：
10.1111/j.1365-2710.2011.01275.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
What is known and Objective: Methotrexate (MTX) is widely used in the management of paediatric cancer with a generally favourable benefit/risk profile. We report an unusual adverse drug reaction with the first course of high-dose MTX in a paediatric patient and review the literature for similar cases. Case summary: An 11-year-old boy with small-cell osteoblastic osteosarcoma in the lower limb experienced a case of lifethreatening anaphylaxis during the first course of high-dose MTX. The adverse event occurred during the first course, likely due to an immune-mediated mechanism. We postulate that prior antineoplastic treatment might have contributed to the immune response to MTX. What is new and Conclusion: Given that this reaction has rarely been reported, we discuss the present case with a review of other similar cases. Further studies are needed to substantiate this ` signal alarm' for serious MTX-related hypersensitivity reactions.
引用
收藏
页码：245 / 248
页数：4
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