P and N type copper phthalocyanines as effective semiconductors in organic thin-film transistor based DNA biosensors at elevated temperatures

被引:53
作者
Boileau, Nicholas T. [1 ]
Melville, Owen A. [1 ]
Mirka, Brendan [1 ]
Cranston, Rosemary [1 ]
Lessard, Benoit H. [1 ]
机构
[1] Univ Ottawa, Dept Chem & Biol Engn, 161 Louis Pasteur, Ottawa, ON K1N 6N5, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
LABEL-FREE; NUCLEIC-ACIDS; HYBRIDIZATION; STABILITY; BIAS; SENSITIVITY; INTERFACES; TRANSPORT; SENSORS; GENOME;
D O I
10.1039/c8ra08829b
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Many health-related diagnostics are expensive, time consuming and invasive. Organic thin film transistor (OTFT) based devices show promise to enable rapid, low cost diagnostics that are an important aspect to enabling increased access and availability to healthcare. Here, we describe OTFTs based upon two structurally similar P (copper phthalocyanine - CuPc) and N (hexdecafluoro copper phthalocyanine - F-16-CuPc) type semiconductor materials, and demonstrate their potential for use as both temperature and DNA sensors. Bottom gate bottom contact (BGBC) OTFTs with either CuPc or F-16-CuPc semiconducting layers were characterized within a temperature range of 25 degrees C to 90 degrees C in both air and under vacuum. CuPc devices showed small positive shifts in threshold voltage (V-T) in air and significant linear increases in mobility with increasing temperature. F-16-CuPc devices showed large negative shifts in V-T in air and linear increases in mobility under the same conditions. Similar OTFTs were exposed to DNA in different hybridization states and both series of devices showed positive V-T increases upon DNA exposure, with a larger response to single stranded DNA. The N-type F-16-CuPc devices showed a much greater sensing response than the P-type CuPc. These findings illustrate the use of these materials, especially the N-type semiconductor, as both temperature and DNA sensors and further elucidate the mechanism of DNA sensing in OTFTs.
引用
收藏
页码:2133 / 2142
页数:10
相关论文
共 53 条
[1]   Next-generation DNA sequencing techniques [J].
Ansorge, Wilhelm J. .
NEW BIOTECHNOLOGY, 2009, 25 (04) :195-203
[2]   Electrical characteristics of ink-jet printed, all-polymer electrochemical transistors [J].
Basirico, L. ;
Cosseddu, P. ;
Scida, A. ;
Fraboni, B. ;
Malliaras, G. G. ;
Bonfiglio, A. .
ORGANIC ELECTRONICS, 2012, 13 (02) :244-248
[3]   Infrared camera assessment of skin surface temperature - Effect of emissivity [J].
Bernard, V. ;
Staffa, E. ;
Mornstein, V. ;
Bourek, A. .
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, 2013, 29 (06) :583-591
[4]   Long-range charge hopping in DNA [J].
Bixon, M ;
Giese, B ;
Wessely, S ;
Langenbacher, T ;
Michel-Beyerle, ME ;
Jortner, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (21) :11713-11716
[5]   The influence of air and temperature on the performance of PBDB-T and P3HT in organic thin film transistors [J].
Brixi, Samantha ;
Melville, Owen A. ;
Boileau, Nicholas T. ;
Lessard, Benoit H. .
JOURNAL OF MATERIALS CHEMISTRY C, 2018, 6 (44) :11972-11979
[6]   Band alignment at organic-inorganic semiconductor interfaces:: α-NPD and CuPc on InP(110) [J].
Chassé, T ;
Wu, CI ;
Hill, IG ;
Kahn, A .
JOURNAL OF APPLIED PHYSICS, 1999, 85 (09) :6589-6592
[7]  
Chen H.-K., 2008, MRS P, V1091
[8]   Organic-Organic Heterojunction Interfaces: Effect of Molecular Orientation [J].
Chen, Wei ;
Qi, Dong-Chen ;
Huang, Han ;
Gao, Xingyu ;
Wee, Andrew T. S. .
ADVANCED FUNCTIONAL MATERIALS, 2011, 21 (03) :410-424
[9]   A label-free biosensor based on organic transistors by using the interaction of mercapto DNA and gold electrodes [J].
Chen, Xiong ;
Gui, Haiyang ;
Wei, Bin ;
Wang, Jun .
MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING, 2015, 35 :127-131
[10]   Variable temperature film and contact resistance measurements on operating n-channel organic thin film transistors [J].
Chesterfield, RJ ;
McKeen, JC ;
Newman, CR ;
Frisbie, CD ;
Ewbank, PC ;
Mann, KR ;
Miller, LL .
JOURNAL OF APPLIED PHYSICS, 2004, 95 (11) :6396-6405