Cortical spreading depression and migraine: new insights from imaging?

被引：39
作者：
James, MF
Smith, JM
Boniface, SJ
Huang, CLH
Leslie, RA
机构：
[1] GlaxoSmithKline, Neurosci Res, Harlow CM19 5AW, Essex, England
[2] John Radcliffe Hosp, MRC, Biochem & Clin Magnet Resonance Unit, Oxford OX1 3QU, England
[3] Addenbrookes Hosp, Dept Clin Neurophysiol, Cambridge CB2 2QQ, England
[4] Addenbrookes Hosp, Wolfson Brain Imaging Ctr, Cambridge CB2 2QQ, England
[5] Univ Cambridge, Physiol Lab, Cambridge CB2 3EG, England
来源：
TRENDS IN NEUROSCIENCES | 2001年 / 24卷 / 05期
关键词：
D O I：
10.1016/S0166-2236(00)01793-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The possibility that spreading depression (SD) of cortical activity, a phenomenon observed in all vertebrates, causes the sura of migraine remains an open question in spite of nearly half a century of investigation. SD is also thought to be associated with the progressive neuronal injury observed during cerebral ischaemia, Thus, the ability to detect and investigate SD in humans m ig ht prove clinically significant,Animal studies of cortical spreading depression (CSD) have benefited greatly from the advent of relatively noninvasive imaging techniques. The use of these new imaging techniques for clinical studies will accelerate progress in this area of neurobiology.
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收藏
页码：266 / 271
页数：6
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