Asymmetric direct amide synthesis by kinetic amine resolution:: A chiral bifunctional aminoboronic acid catalyzed reaction between a racemic amine and an achiral carboxylic acid

被引：157
|
作者：
Arnold, Kenny [1 ]
Davies, Bryan [2 ]
Herault, Damien [1 ]
Whiting, Andrew [1 ]
机构：
[1] Univ Durham, Dept Chem, Sci Labs, Durham DH1 3QZ, England
[2] GlaxoSmithKline, Discovery Res Syst Chem, Stevenage SG1 2NY, Herts, England
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 14期
关键词：
boronates; homogeneous catalysis; kinetic resolution; selectivity;
D O I：
10.1002/anie.200705643
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Let's resolve this: A planar chiral benzimidazole ferroceneboronic acid catalyst demonstrates low to moderate asymmetric induction in the kinetic resolution of racemic α-substituted benzylamines by direct amide formation with achiral carboxylic acids (see scheme). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：2673 / 2676
页数：4
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