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Imbalance between endothelial progenitors cells and microparticles in HIV-infected patients naive for antiretroviral therapy
被引:45
作者:
da Silva, Erika F. R.
[1
]
Fonseca, Francisco A. H.
[2
]
Franca, Carolina N.
[2
]
Ferreira, Paulo R. A.
[1
]
Izar, Maria C. O.
[2
]
Salomao, Reinaldo
[1
]
Camargo, Luciano M.
[2
]
Tenore, Simone B.
[1
]
Lewi, David S.
[1
]
机构:
[1] Univ Fed Sao Paulo, Div Infect Dis, Sao Paulo, Brazil
[2] Univ Fed Sao Paulo, Cardiovasc Div, Lipids Atherosclerosis & Vasc Biol Sect, Sao Paulo, Brazil
来源:
基金:
巴西圣保罗研究基金会;
关键词:
endothelial progenitor cells;
endothelial-derived microparticles;
HIV infection;
inflammation;
platelet-derived microparticles;
LOW-DENSITY-LIPOPROTEIN;
DISEASE RISK-FACTORS;
C-REACTIVE PROTEIN;
MEMBRANE MICROPARTICLES;
CARDIOVASCULAR-DISEASE;
ATHEROSCLEROSIS;
DIFFERENTIATION;
ANGIOGENESIS;
MOBILIZATION;
ACTIVATION;
D O I:
10.1097/QAD.0b013e32834980f4
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Background: Cardiovascular events have been reported among HIV-infected patients following antiretroviral therapy. However, the role of HIV itself in determining vascular damage is less described. Chronic inflammatory state might impair some regulatory endothelium properties leading to its activation, apoptosis or erosion. Objectives: To evaluate the balance between endothelial progenitor cells and micro-particles in HIV-infected antiretroviral drug-naive patients. Design: A case-control study comparing HIV-infected patients (n = 35) with sex-matched and age-matched healthy controls (n = 33). Methods: Endothelial progenitor cells populations expressing CD34(+), CD133(+) and KDR+ were quantified by flow cytometry. Endothelial-derived microparticles, expressing CD51(+), and platelet-derived microparticles, expressing CD31(+)/CD42(+), were also measured. Endothelial function was estimated by flow-mediated dilation. Results: Lower percentages of endothelial progenitor cells (CD34(+)/KDR+) were observed in HIV-infected individuals compared with controls (0.02 vs. 0.09%, P = 0.045). In addition, endothelial microparticles concentration was higher in HIV-infected individuals (1963 vs. 436 microparticles/ml platelet-poor plasma, P = 0.003), with similar number of platelet-derived microparticles among groups. Furthermore, flow-mediated dilation was lower among HIV-infected individuals compared with controls [mean (SEM): 10 (1) and 16% (2), respectively; P = 0.03]. Conclusion: Our findings suggest an imbalance between endothelial progenitor cells mobilization and endothelial apoptosis. The alteration in the turnover of endothelial cells may contribute to cardiovascular events in HIV-infected patients. (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins
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页码:1595 / 1601
页数:7
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