Kidney organoids-a new tool for kidney therapeutic development

被引：16

作者：

Bonventre, Joseph V. ^{[1
,2
,3
]}

机构：

[1] Brigham & Womens Hosp, Div Renal, Boston, MA 02115 USA

[2] Harvard Med Sch, Dept Med, Boston, MA USA

[3] Harvard Stem Cell Inst, Cambridge, MA USA

来源：

KIDNEY INTERNATIONAL | 2018年 / 94卷 / 06期

关键词：

D O I：

10.1016/j.kint.2018.07.029

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Kidney organoids, derived from human pluripotent stem cells, have the potential to greatly facilitate drug development. Borestrom et al. have used CRISPR/Cas9 to create kidney fluorescent lineage markers for SIX2 and NPHS1 to monitor the differentiation process to tubular and glomerular structures and optimize maturity. The convergence of "personalized" kidney organoids with genome editing and single-cell sequencing technology hold great promise to result in better insight to disease, better human cell disease models, more predictive toxicology, and potentially "clinical trials in a dish." Copyright (C) 2018, Published by Elsevier, Inc., on behalf of the International Society of Nephrology.

引用

收藏

页码：1040 / 1042

页数：3

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