WHITE MATTER ASYMMETRY IN HEALTHY INDIVIDUALS: A DIFFUSION TENSOR IMAGING STUDY USING TRACT-BASED SPATIAL STATISTICS

被引：52
作者：
Takao, H. [1 ]
Hayashi, N. [2 ]
Ohtomo, K. [1 ]
机构：
[1] Univ Tokyo, Grad Sch Med, Dept Radiol, Bunkyo Ku, Tokyo 1138655, Japan
[2] Univ Tokyo, Grad Sch Med, Dept Computat Diagnost Radiol & Prevent Med, Bunkyo Ku, Tokyo 1138655, Japan
来源：
NEUROSCIENCE | 2011年 / 193卷
关键词：
brain; fractional anisotropy; laterality; lateralization; magnetic resonance imaging; ARCUATE FASCICULUS; HUMAN BRAIN; CORTICOSPINAL TRACT; UNCINATE FASCICULUS; CINGULUM ABNORMALITIES; STRUCTURAL ASYMMETRIES; VOXELWISE ANALYSIS; LANGUAGE NETWORKS; SEX-DIFFERENCES; FIBER TRACKING;
D O I：
10.1016/j.neuroscience.2011.07.041
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The purpose of this study was to investigate white matter asymmetry across the whole brain and evaluate the effects of age and sex on white matter asymmetry in a large sample of healthy adults. A total of 857 normal subjects (310 females and 547 males, mean age=56.1 +/- 9.9 years, age range=24.9-84.8 years) were included in this study. With use of tract-based spatial statistics (TBSS), we investigated white matter fractional anisotropy (FA) asymmetry and evaluated the effects of age and sex on white matter FA asymmetry. The voxel-wise analysis showed a large number of white matter FA asymmetries including leftward asymmetry of the arcuate fasciculus and cingulum. The effects of age and sex on white matter FA asymmetry were minor compared to overall FA asymmetries. Small regions showed a significant effect of age or sex, due to the large sample, but this may not be relevant in practice. There was no significant interaction between age and sex. The results of our study demonstrate white matter asymmetry in healthy adults and suggest that white matter asymmetry is relatively stable during aging and not much different between males and females. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
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页码：291 / 299
页数：9
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