Electron deficiency of aldehydes controls the pyrrolidine catalyzed direct cross-aldol reaction of aromatic/heterocyclic aldehydes and ketones in water

被引：57

作者：

Chimni, SS ^{[1
]}

Mahajan, D ^{[1
]}

机构：

[1] Guru Nanak Dev Univ, Dept Chem, Amritsar 143005, Punjab, India

来源：

TETRAHEDRON | 2005年 / 61卷 / 21期

关键词：

pyrrolidine catalysis; heterocyclic aldol; cross-aldol; aqueous medium; beta-hydroxy ketones;

D O I：

10.1016/j.tet.2005.03.045

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthetically useful pyrrolidine catalyzed direct cross-aldol reaction of aromatic/heterocyclic aldehydes with ketones in water affords the aldol addition product in up to 93% yield. Electrophilicity of the aldehydes controls the course of the reaction. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：5019 / 5025

页数：7

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