Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine

被引：236

作者：

Payne, Rebecca P. ^{[1
]}

Longet, Stephanie ^{[2
]}

Austin, James A. ^{[3
]}

Skelly, Donal T. ^{[4
,5
,6
]}

Dejnirattisai, Wanwisa ^{[2
]}

Adele, Sandra ^{[4
]}

Meardon, Naomi ^{[7
]}

Faustini, Sian ^{[8
]}

Al-Taei, Saly ^{[8
]}

Moore, Shona C. ^{[3
]}

Tipton, Tom ^{[2
]}

Hering, Luisa M. ^{[3
]}

Angyal, Adrienn ^{[9
]}

Brown, Rebecca ^{[9
]}

Nicols, Alexander R. ^{[1
]}

Gillson, Natalie ^{[10
]}

Dobson, Susan L. ^{[3
]}

Amini, Ali ^{[5
,11
]}

Supasa, Piyada ^{[2
]}

Cross, Andrew ^{[12
]}

Bridges-Webb, Alice ^{[13
]}

Reyes, Laura Silva ^{[13
]}

Linder, Aline ^{[13
]}

Sandhar, Gurjinder ^{[9
]}

Kilby, Jonathan A. ^{[9
]}

Tyerman, Jessica K. ^{[1
]}

Altmann, Thomas ^{[1
,14
]}

Hornsby, Hailey ^{[9
]}

Whitham, Rachel ^{[7
]}

Phillips, Eloise ^{[4
]}

Malone, Tom ^{[4
]}

Hargreaves, Alexander ^{[2
]}

Shields, Adrian ^{[8
,15
]}

Saei, Ayoub ^{[10
]}

Foulkes, Sarah ^{[10
]}

Stafford, Lizzie ^{[5
]}

Johnson, Sile ^{[4
,5
,16
]}

Wootton, Daniel G. ^{[3
,12
,17
]}

Conlon, Christopher P. ^{[5
,18
]}

Jeffery, Katie ^{[5
,19
]}

Matthews, Philippa C. ^{[4
,5
]}

Frater, John ^{[4
,5
]}

Deeks, Alexandra S. ^{[4
,5
]}

Pollard, Andrew J. ^{[13
,20
]}

Brown, Anthony ^{[4
]}

Rowland-Jones, Sarah L. ^{[7
,9
]}

Mongkolsapaya, Juthathip ^{[2
,21
,22
]}

Barnes, Eleanor ^{[4
,5
,11
,20
]}

Hopkins, Susan ^{[10
,23
,24
]}

Hall, Victoria ^{[10
,24
]}

机构：

[1] Newcastle Univ, Translat & Clin Res Inst Immun & Inflammat Theme, Newcastle Upon Tyne, Tyne & Wear, England

[2] Univ Oxford, Wellcome Ctr Human Genet, Nuffield Dept Med, Oxford, England

[3] Univ Liverpool, Inst Infect Vet & Ecol Sci, NIHR Hlth Protect Res Unit Emerging & Zoonot Infe, Liverpool, Merseyside, England

[4] Univ Oxford, Nuffield Dept Clin Med, Peter Medawar Bldg Pathogen Res, Oxford, England

[5] Oxford Univ Hosp NHS Fdn Trust, Oxford, England

[6] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford, England

[7] Sheffield Teaching Hosp NHS Fdn Trust, Sheffield, S Yorkshire, England

[8] Univ Birmingham, Coll Med & Dent Sci, Inst Immunol & Immunotherapy, Birmingham, W Midlands, England

[9] Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield, S Yorkshire, England

[10] Publ Hlth England, London, England

[11] Univ Oxford, Translat Gastroenterol Unit, Oxford, England

[12] Liverpool Univ Hosp NHS Fdn Trust, Liverpool, Merseyside, England

[13] Univ Oxford, Dept Paediat, Oxford Vaccine Grp, Oxford, England

[14] Great North Childrens Hosp, Newcastle Upon Tyne, Tyne & Wear, England

[15] Univ Hosp Birmingham NHS Fdn Trust, Birmingham, W Midlands, England

[16] Univ Oxford, Med Sch, Med Sci Div, Oxford, England

[17] Univ Liverpool, Inst Infect Vet & Ecol Sci, Liverpool, Merseyside, England

[18] Univ Oxford, Oxford Ctr Global Hlth Res, Nuffield Dept Clin Med, Oxford, England

[19] Univ Oxford, Radcliffe Dept Med, Oxford, England

[20] Univ Oxford, NIHR Oxford Biomed Res Ctr, Oxford, England

[21] Univ Oxford, Chinese Acad Med Sci CAMS, Oxford Inst COI, Oxford, England

[22] Mahidol Univ, Fac Med, Siriraj Ctr Res Excellence Dengue & Emerging Path, Siriraj Hosp, Bangkok, Thailand

[23] Imperial Coll London, Fac Med, Dept Infect Dis, London, England

[24] Univ Oxford, NIHR Hlth Protect Res Unit Healthcare Associated, Oxford, England

[25] Newcastle Upon Tyne Hosp NHS Fdn Trust, Dept Infect & Trop Med, Newcastle Upon Tyne, Tyne & Wear, England

[26] Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand

来源：

CELL | 2021年 / 184卷 / 23期

基金：

英国惠康基金; 美国国家卫生研究院;

关键词：

CELLS;

D O I：

10.1016/j.cell.2021.10.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Extension of the interval between vaccine doses for the BNT162b2 mRNA vaccine was introduced in the United Kingdom to accelerate population coverage with a single dose. At this time, trial data were lacking, and we addressed this in a study of United Kingdom healthcare workers. The first vaccine dose induced protection from infection from the circulating alpha (B.1.1.7) variant over several weeks. In a substudy of 589 individuals, we show that this single dose induces severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibody (NAb) responses and a sustained B and T cell response to the spike protein. NAb levels were higher after the extended dosing interval (6-14 weeks) compared with the conventional 3-to 4-week regimen, accompanied by enrichment of CD4(+) T cells expressing interleukin-2 (IL-2). Prior SARS-CoV-2 infection amplified and accelerated the response. These data on dynamic cellular and humoral responses indicate that extension of the dosing interval is an effective immunogenic protocol.

引用

页码：5699 / +

页数：28

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