In Vitro Inhibitory Effects of Cyandin-3-rutinoside on Pancreatic α-Amylase and Its Combined Effect with Acarbose

被引：69

作者：

Akkarachiyasit, Sarinya ^{[2
]}

Yibchok-Anun, Sirintorn ^{[2
]}

Wacharasindhu, Sumrit ^{[3
]}

Adisakwattana, Sirichai ^{[1
]}

机构：

[1] Chulalongkorn Univ, Dept Transfus Med, Fac Allied Hlth Sci, Med Food Res & Dev Ctr, Bangkok 10330, Thailand

[2] Chulalongkorn Univ, Dept Pharmacol, Fac Vet Sci, Bangkok 10330, Thailand

[3] Chulalongkorn Univ, Nat Prod Res Unit, Dept Chem, Fac Sci, Bangkok 10330, Thailand

来源：

MOLECULES | 2011年 / 16卷 / 03期

关键词：

cyanidin-3-rutinoside; pancreatic alpha-amylase; acarbose; additive inhibition; GLUCOSIDASE INHIBITORS; CYANIDIN; 3-RUTINOSIDE; ANTIOXIDANT ACTIVITY; ANTHOCYANINS; CYANIDIN-3-RUTINOSIDE; PREVENTION; RICE;

D O I：

10.3390/molecules16032075

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The inhibitory activity on pancreatic alpha-amylase by cyanidin-3-rutinoside was examined in vitro. The IC50 value of cyanidin-3-rutinoside against pancreatic alpha-amylase was 24.4 +/- 0.1 mu M. The kinetic analysis revealed that pancreatic mu-amylase was inhibited by cyanidin-3-rutinoside in a non-competitive manner. The additive inhibition of a combination of cyanidin-3-rutinoside with acarbose against pancreatic alpha-amylase was also found. These results provide the first evidence for the effect of cyanidin-3-rutinoside in a retarded absorption of carbohydrates by inhibition of pancreatic alpha-amylase which may be useful as a potential inhibitor for prevention and treatment of diabetes mellitus.

引用

页码：2075 / 2083

页数：9

共 25 条

[1] Inhibitory activity of cyanidin-3-rutinoside on α-glucosidase [J].