Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis

被引：36

作者：

da Silva, Vandeclecio Lira ^{[1
,2
,3
]}

Fonseca, Andre Faustino ^{[1
,2
,3
]}

Fonseca, Marbella ^{[1
]}

da Silva, Thayna Emilia ^{[1
]}

Coelho, Ana Carolina ^{[1
,3
]}

Kroll, Jose Eduardo ^{[1
,3
,4
]}

Santana de Souza, Jorge Estefano ^{[3
,5
]}

Stransky, Beatriz ^{[3
,6
]}

de Souza, Gustavo Antonio ^{[1
,3
]}

de Souza, Sandro Jose ^{[1
,3
]}

机构：

[1] Univ Fed Rio Grande do Norte, Inst Cerebro, Natal, RN, Brazil

[2] Univ Fed Rio Grande do Norte, PhD Program Bioinformat, Natal, RN, Brazil

[3] Univ Fed Rio Grande do Norte, Digital Metropolis Inst, Bioinformat Multidisciplinary Environm BioME, Natal, RN, Brazil

[4] Inst Bioinformat & Biotecnol, Natal, RN, Brazil

[5] Univ Fed Rio Grande do Norte, Inst Metropole Digital, Natal, RN, Brazil

[6] Univ Fed Rio Grande do Norte, Dept Engn Biomed, Natal, RN, Brazil

来源：

ONCOTARGET | 2017年 / 8卷 / 54期

关键词：

cancer/testis; cancer antigens; biomarkers; prognosis; SQUAMOUS-CELL CARCINOMA; EXPRESSION PATTERN; PROSTATE-CANCER; TESTIS ANTIGEN; T-CELLS; MAGE-A; IMMUNOTHERAPY; NY-ESO-1; TARGETS; ACTIVATION;

D O I：

10.18632/oncotarget.21715

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer/testis (CT) genes are excellent candidates for cancer immunotherapies because of their restrict expression in normal tissues and the capacity to elicit an immune response when expressed in tumor cells. In this study, we provide a genomewide screen for CT genes with the identification of 745 putative CT genes. Comparison with a set of known CT genes shows that 201 new CT genes were identified. Integration of gene expression and clinical data led us to identify dozens of CT genes associated with either good or poor prognosis. For the CT genes related to good prognosis, we show that there is a direct relationship between CT gene expression and a signal for CD8+ cells infiltration for some tumor types, especially melanoma.

引用

页码：92966 / 92977

页数：12

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