Nerve growth factor regulates VR-1 mRNA levels in cultures of adult dorsal root ganglion neurons

被引：157

作者：

Winston, J ^{[1
]}

Toma, H ^{[1
]}

Shenoy, M ^{[1
]}

Pasricha, PJ ^{[1
]}

机构：

[1] Univ Texas, Med Branch,Dept Internal Med, Enter Neuromuscular Dis & Pain Lab, Div Gastroenterol & Hepatol, Galveston, TX 77555 USA

来源：

PAIN | 2001年 / 89卷 / 2-3期

关键词：

nerve growth factor; dorsal root ganglion; vanilloid receptor; calcitonin gene related peptide release;

D O I：

10.1016/S0304-3959(00)00370-5

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Nerve growth factor (NGF) regulates the nociceptive properties including sensitivity to capsaicin of a subset of dorsal root ganglion neurons, which express the high-affinity NGF receptor, trkA. Capsaicin sensitivity co-localizes with the expression of a cloned capsaicin receptor, vanilloid receptor type 1 (VR-1), which displays properties similar to the native capsaicin response. To determine whether VP-1 mRNA levels are regulated by NGF, VP-1 mRNA levels and the ability to respond to capsaicin by release of the neuropeptide calcitonin gene related peptide (CGRP) were measured as a function of NGF concentration in cultures of adult dorsal root ganglion neurons. NGF treatment increased both VP-1 mRNA expression and capsaicin evoked release of CGRP. These effects: were inhibited by treatment with the trkA inhibitor k252a. (C) 2001 International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reserved..

引用

页码：181 / 186

页数：6

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