The new era of nanotechnology, an alternative to change cancer treatment

被引：128
作者：
Jurj, Ancuta [1 ]
Braicu, Cornelia [1 ]
Pop, Laura-Ancuta [1 ]
Tomuleasa, Ciprian [1 ,2 ]
Gherman, Claudia Diana [3 ,4 ]
Berindan-Neagoe, Ioana [1 ,5 ,6 ]
机构：
[1] Univ Med & Pharm Iuliu Hatieganu, Res Ctr Funct Gen Biomed & Translat Med, Cluj Napoca, Romania
[2] Oncol Inst Prof Dr Ion Chiricuta, Dept Hematol, Cluj Napoca, Romania
[3] Univ Med & Pharm Iuliu Hatieganu, Dept Med Educ, Pract Abil, Cluj Napoca, Romania
[4] Univ Med & Pharm Iuliu Hatieganu, Dept Med Educ, Cluj Napoca, Romania
[5] Oncol Inst Prof Dr Ion Chiricuta, Dept Funct Genom & Expt Pathol, Cluj Napoca, Romania
[6] Univ Med & Pharm Iuliu Hatieganu, MedFuture Res Ctr Adv Med, Cluj Napoca, Romania
来源：
DRUG DESIGN DEVELOPMENT AND THERAPY | 2017年 / 11卷
关键词：
nanotechnology; gold nanoparticles; liposomes; dendrimers; microRNA; RNA interference; PEGYLATED LIPOSOMAL DOXORUBICIN; POLY ETHYLENE-GLYCOL; B-CELL LYMPHOMA; CONJUGATED GOLD NANOPARTICLES; DRUG-DELIVERY; BREAST-CANCER; IN-VIVO; CARBON NANOTUBES; POLY(ETHYLENE GLYCOL); GENE DELIVERY;
D O I：
10.2147/DDDT.S142337
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In the last few years, nanostructures have gained considerable interest for the safe delivery of therapeutic agents. Several therapeutic approaches have been reported, such as molecular diagnosis, disease detection, nanoscale immunotherapy and anticancer drug delivery that could be integrated into clinical use. The current paper aims to highlight the background that supports the use of nanoparticles conjugated with different types of therapeutic agents, applicable in targeted therapy and cancer research, with a special emphasis on hematological malignancies. A particular key point is the functional characterization of nonviral delivery systems, such as gold nanoparticles, liposomes and dendrimers. The paper also presents relevant published data related to microRNA and RNA interference delivery using nanoparticles in cancer therapy.
引用
收藏
页码：2871 / 2890
页数：20
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