Visible-light-promoted Cascade Reaction of Acryloylbenzamides with Carboxylic Acids: Metal-free Synthesis of Isoquinolinediones

被引：7
|
作者：
Cai, Xingxing [1 ]
Fu, Jiahui [1 ]
Gu, Li [1 ]
Cheng, Dongping [2 ]
Wang, Hong [1 ]
Xu, Xiaoliang [1 ]
机构：
[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Peoples R China
[2] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 11卷 / 08期
关键词：
Acryloylbenzamides; Decarboxylation; Isoquinolinediones; Radical reaction; Visible light; PHOTOREDOX CATALYSIS; RNASE-H; DECARBOXYLATION; INHIBITORS; DESIGN;
D O I：
10.1002/ajoc.202200318
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A metal-free and mild cascade reaction of acryloylbenzamides with carboxylic acids and alpha-imino oxy acid is developed. It undergoes decarboxylation, radical addition, and intramolecular cyclization in the presence of visible light, providing 4-substituted-isoquinoline-1,3(2H,4H)-diones in moderate to good yields.
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页数：7
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