Grignard exchange reaction using a microflow system: From bench to pilot plant

被引：89

作者：

Wakami, H

Yoshida, J ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Engn, Dept Synthet Chem & Biol Chem, Nishikyo Ku, Kyoto 6158510, Japan

[2] Kyoto Univ, Res Assoc MCPT, Kyoto 6158510, Japan

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2005年 / 9卷 / 06期

关键词：

D O I：

10.1021/op0501500

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The Grignard exchange reaction of ethylmagnesium bromide (EtMgBr) and bromopentafluorobenzene (BPFB) to give pentafluorophenylmagnesium bromide (PFPMgBr) was carried out using small- and medium-scale microflow systems consisting of a micromixer and a microheat exchanger. The results indicate that the microflow systems are quite effective. On the basis of the data obtained, a pilot that involves the Toray Hi-mixer connected to a shell and tube microheat exchanger was constructed. Continuous operation for 24 h was accomplished without any problem to obtain pentafluorobenzene (PFB) after protonation (92% yield).

引用

页码：787 / 791

页数：5

共 65 条

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