AChR myasthenia gravis switching to MuSK or double antibody positive myasthenia gravis in two children and literature review

被引：7

作者：

Lu, Yaru ^{[1
,2
]}

Ran, Hao ^{[3
]}

Yang, Wenhao ^{[1
,2
]}

Ma, Qian ^{[1
,2
]}

Qiu, Li ^{[1
,2
]}

Ou, Changyi ^{[1
,2
]}

Chen, Pei ^{[1
,2
]}

Lin, Zhongqiang ^{[1
,2
]}

Liu, Weibin ^{[1
,2
]}

机构：

[1] Sun Yat Sen Univ, Natl Key Clin Dept, Dept Neurol, Affiliated Hosp 1, Guangzhou 510080, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 1, Key Discipline Neurol, Guangzhou 510080, Peoples R China

[3] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China

来源：

NEUROMUSCULAR DISORDERS | 2020年 / 30卷 / 07期

关键词：

Myasthenia gravis; Achr antibody; Musk antibody; Children; CLINICAL CHARACTERISTICS; TYROSINE KINASE; AUTOANTIBODIES;

D O I：

10.1016/j.nmd.2020.03.012

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Muscle-specific tyrosine kinase antibody (MuSK-Ab) and acetylcholine receptor antibody (AChR-Ab) coexistence in myasthenia gravis (MG) is very rare. In this report, two children with AChR-Ab switching to double antibody positive MG (DP-MG) or MuSK-Ab positive MG (MuSK-MG) are described. Six similar cases were found in the literature via online database search. Therefore, this study describes eight patients in total, six female and two male. The average age of onset was 7.25 +/- 5.95 years. Four AChR-MG patients switched to DP-MG with no known precipitating factor and four switched after thymectomy (two to MuSK-MG and two to DP-MG). After the serological switch, the patients transitioned to the phenotype of MuSK-MG and responded poorly to cholinesterase inhibitors and well to corticosteroids and plasma exchange. (C) 2020 Elsevier B.V. All rights reserved.

引用

页码：534 / 538

页数：5

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