Mitochondrial translation, dynamics, and lysosomes combine to extend lifespan

被引：2

作者：

Ali, Levi ^{[1
]}

Haynes, Cole M. ^{[1
]}

机构：

[1] Univ Massachusetts, Med Sch, Dept Mol Cell & Canc Biol, Worcester, MA 01605 USA

来源：

JOURNAL OF CELL BIOLOGY | 2020年 / 219卷 / 06期

关键词：

D O I：

10.1083/jcb.202005084

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In this issue, Liu et al. (2019. J. Cell. Biol. https://doi.org/10.1083/jcb.201907067) find that the inhibition of mitochondrial ribosomes in combination with impaired mitochondrial fission or fusion increases C. elegans lifespan by activating the transcription factor HLH-30, which promotes lysosomal biogenesis.

引用

页数：2

共 50 条

[1] Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30
Liu, Yasmine J.
McIntyre, Rebecca L.
Janssens, Georges E.
Williams, Evan G.
Lan, Jiayi
van Weeghel, Michel
Schomakers, Bauke
van der Veen, Henk
van der Wel, Nicole N.
Yao, Pallas
Mair, William B.
Aebersold, Ruedi
MacInnes, Alyson W.
Houtkooper, Riekelt H.
JOURNAL OF CELL BIOLOGY, 2020, 219 (06):
[2] Mitochondrial metabolites extend lifespan
Mishur, Robert J.
Khan, Maruf
Munkacsy, Erin
Sharma, Lokendra
Bokov, Alex
Beam, Haley
Radetskaya, Oxana
Borror, Megan
Lane, Rebecca
Bai, Yidong
Rea, Shane L.
AGING CELL, 2016, 15 (02) : 336 - 348
[3] The UPRmt preserves mitochondrial import to extend lifespan
Xin, Nan
Durieux, Jenni
Yang, Chunxia
Wolff, Suzanne
Kim, Hyun-Eui
Dillin, Andrew
JOURNAL OF CELL BIOLOGY, 2022, 221 (07):
[4] Mitochondrial reactive oxygen species: Do they extend or shorten animal lifespan
Sanz, Alberto
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2016, 1857 (08): : 1116 - 1126
[5] Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan
Scialo, Filippo
Sriram, Ashwin
Fernandez-Ayala, Daniel
Gubina, Nina
Lohmus, Madis
Nelson, Glyn
Logan, Angela
Cooper, Helen M.
Navas, Placido
Antonio Enriquez, Jose
Murphy, Michael P.
Sanz, Alberto
CELL METABOLISM, 2016, 23 (04) : 725 - 734
[6] Coffee may extend lifespan
Bartelme, Melanie Zanoza
FOOD TECHNOLOGY, 2017, 71 (09) : 14 - 15
[7] Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance
Ye, Lan
Widlund, Anne L.
Sims, Carrie A.
Lamming, Dudley W.
Guan, Yuxia
Davis, James G.
Sabatini, David M.
Harrison, David E.
Vang, Ole
Baur, Joseph A.
AGING-US, 2013, 5 (07): : 539 - 550
[8] Mitochondrial electron transport chain dysfunction during development does not extend lifespan in Drosophila melanogaster
Rera, Michael
Monnier, Veronique
Tricoire, Herve
MECHANISMS OF AGEING AND DEVELOPMENT, 2010, 131 (02) : 156 - 164
[9] Translation kinetics and diffusive timescales can combine to regulate mitochondrial localization of mRNAs
Arceo, Ximena Garcia
Zid, Brian M.
Brown, Aidan
Koslover, Elena F.
BIOPHYSICAL JOURNAL, 2022, 121 (03) : 122 - 122
[10] Can oxygen anosmia extend lifespan?
Abergel, Rachel
Gross, Einav
AGING-US, 2017, 9 (11): : 2241 - 2242

← 1 2 3 4 5 →