Super-resolution links vinculin localization to function in focal adhesions

被引：14
作者：
Giannone, Gregory [1 ,2 ]
机构：
[1] Univ Bordeaux, Interdisciplinary Inst Neurosci, UMR 5297, F-33000 Bordeaux, France
[2] CNRS, Interdisciplinary Inst Neurosci, UMR 5297, F-33000 Bordeaux, France
来源：
NATURE CELL BIOLOGY | 2015年 / 17卷 / 07期
关键词：
TALIN; ACTIVATION; MECHANISMS;
D O I：
10.1038/ncb3196
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Integrin-based focal adhesions integrate biochemical and biomechanical signals from the extracellular matrix and the actin cytoskeleton. The combination of three-dimensional super-resolution imaging and loss- or gain-of-function protein mutants now links the nanoscale dynamic localization of proteins to their activation and function within focal adhesions.
引用
收藏
页码：845 / 847
页数：3
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