Sex-specific longevity associations defined by Tyrosine Hydroxylase-Insulin-Insulin Growth Factor 2 haplotypes on the 11p15.5 chromosomal region

被引：37
作者：
De Luca, M [1 ]
Rose, G
Bonafè, A
Garasto, S
Greco, V
Weir, BS
Franceschi, C
De Benedictis, G
机构：
[1] Univ Calabria, Dept Cell Biol, I-87030 Arcavacata Di Rende, Italy
[2] Univ Bologna, Dept Expt Pathol, I-40126 Bologna, Italy
[3] N Carolina State Univ, Dept Stat, Raleigh, NC 27695 USA
来源：
EXPERIMENTAL GERONTOLOGY | 2001年 / 36卷 / 10期
关键词：
centenarians; TH gene; INS gene; IGF2; gene; linkage disequilibrium;
D O I：
10.1016/S0531-5565(01)00146-2
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
By studies in centenarians, it was recently found that an STR marker of the Tyrosine Hydroxylase (TH, 11p15.5) gene is associated with human longevity. The aim of the present study was to continue the exploration of the 11p15.5 chromosomal region in human longevity by analyzing two additional RFLP markers, which lie in the Insulin (INS) and Insulin Growth Factor 2 (IGF2) genes. Both the genes, which are localized downstream TH, are indeed good candidates in longevity, as ascertained on the basis of laboratory studies in experimental models. Neither INS nor IGF2 markers did reveal association with longevity. Nevertheless, link-age disequilibrium analyses showed sex-specific longevity associations defined by both TH-INS and TH-IGF2 haplotypes. On the whole, the results reinforce the involvement of the chromosomal region spanning from TH to IGF2 loci in controlling the longevity phenotype in humans. (C) 2001 Elsevier Science Inc. All rights reserved.
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收藏
页码：1663 / 1671
页数：9
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