Historical Overview of Immunological Tolerance

被引：41
作者：
Schwartz, Ronald H. [1 ]
机构：
[1] NIAID, Lab Cellular & Mol Immunol, NIH, Bethesda, MD 20892 USA
来源：
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2012年 / 4卷 / 04期
关键词：
REGULATORY T-CELLS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; FC-GAMMA-RIIB; PLASMACYTOID DENDRITIC CELLS; E3 UBIQUITIN LIGASE; B-CELLS; IMMUNE-SYSTEM; IN-VIVO; SUSCEPTIBILITY LOCUS; NEGATIVE SELECTION;
D O I：
10.1101/cshperspect.a006908
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A fundamental property of the immune system is its ability to mediate self-defense with a minimal amount of collateral damage to the host. The system uses several different mechanisms to achieve this goal, which is collectively referred to as the "process of immunological tolerance." This article provides an introductory historical overview to these various mechanisms, which are discussed in greater detail throughout this collection, and then briefly describes what happens when this process fails, a state referred to as "autoimmunity."
引用
收藏
页数：14
相关论文
共 178 条
  • [1] Aire's Partners in the Molecular Control of Immunological Tolerance
    Abramson, Jakub
    Giraud, Matthieu
    Benoist, Christophe
    Mathis, Diane
    [J]. CELL, 2010, 140 (01) : 123 - 135
  • [2] T-cell regulation by CD28 and CTLA-4
    Alegre, ML
    Frauwirth, KA
    Thompson, CB
    [J]. NATURE REVIEWS IMMUNOLOGY, 2001, 1 (03) : 220 - 228
  • [3] Projection of an immunological self shadow within the thymus by the aire protein
    Anderson, MS
    Venanzi, ES
    Klein, L
    Chen, ZB
    Berzins, SP
    Turley, SJ
    von Boehmer, H
    Bronson, R
    Dierich, A
    Benoist, C
    Mathis, D
    [J]. SCIENCE, 2002, 298 (5597) : 1395 - 1401
  • [4] In vivo instruction of suppressor commitment in naive T cells
    Apostolou, I
    von Boehmer, H
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (10) : 1401 - 1408
  • [5] ASHERSON GL, 1965, IMMUNOLOGY, V9, P205
  • [6] An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
    Asseman, C
    Mauze, S
    Leach, MW
    Coffman, RL
    Powrie, F
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (07) : 995 - 1003
  • [7] Association of CTLA4 polymorphism with regulatory T cell frequency
    Atabani, SF
    Thio, CL
    Divanovic, S
    Trompette, A
    Belkaid, Y
    Thomas, DL
    Karp, CL
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2005, 35 (07) : 2157 - 2162
  • [8] FcγRIIB regulation of BCR/TLR-dependent autoreactive B-cell responses
    Avalos, Ana M.
    Uccellini, Melissa B.
    Lenert, Petar
    Viglianti, Gregory A.
    Marshak-Rothstein, Ann
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2010, 40 (10) : 2692 - 2698
  • [9] CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity
    Azzam, HS
    Grinberg, A
    Lui, K
    Shen, H
    Shores, EW
    Love, PE
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (12) : 2301 - 2311
  • [10] HIGH-LEVELS OF INTERLEUKIN-10 PRODUCTION IN-VIVO ARE ASSOCIATED WITH TOLERANCE IN SCID PATIENTS TRANSPLANTED WITH HLA MISMATCHED HEMATOPOIETIC STEM-CELLS
    BACCHETTA, R
    BIGLER, M
    TOURAINE, JL
    PARKMAN, R
    TOVO, PA
    ABRAMS, J
    MALEFYT, RD
    DEVRIES, JE
    RONCAROLO, MG
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (02) : 493 - 502
12345678910