Synthesis and rheological properties of polylactide/poly(ethylene glycol) multiblock copolymers

被引：45
作者：
Li, F
Li, SM
Vert, M
机构：
[1] Fac Pharm Montpellier, Ctr Rech Biopolymeres Artificiels, F-34060 Montpellier, France
[2] Wuhan Univ, Coll Chem & Mol Sci, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Peoples R China
来源：
MACROMOLECULAR BIOSCIENCE | 2005年 / 5卷 / 11期
关键词：
block copolymers; bioresorbable; hydrogel; poly(ethylene glycol); polylactide;
D O I：
10.1002/mabi.200500143
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ring-opening polymerization of D,L-lactide was carried out in the presence of poly(ethylene glycol), using Zn powder as catalyst. The hydroxyl-capped PLA-PEG-PLA triblock copolymers were coupled with adipoyl chloride at different molar ratios under mild conditions. N-Dimethylaminopyridine (DMAP) was used as catalyst of the coupling reaction. The resulting PLA/PEG multi-block copolymers were characterized by various analytical techniques such as IR, H-1 NMR, SEC, and DSC. Sol-gel transition properties of the multiblock copolymers were investigated by mechanical rheology. The data showed that the sol-gel transition temperature and the transition modulus increased with increasing molecular weight and the solution concentration of the multiblock copolymers.
引用
收藏
页码：1125 / 1131
页数：7
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