Anodal Transcranial Pulsed Current Stimulation: The Effects of Pulse Duration on Corticospinal Excitability

被引：30
作者：
Jaberzadeh, Shapour [1 ]
Bastani, Andisheh [1 ,2 ]
Zoghi, Maryam [2 ]
Morgan, Prue [1 ]
Fitzgerald, Paul B. [3 ]
机构：
[1] Monash Univ, Dept Physiotherapy, Sch Primary Hlth Care, Fac Med, Melbourne, Vic 3004, Australia
[2] Univ Melbourne, Royal Melbourne Hosp, Dept Med, Melbourne, Vic 3050, Australia
[3] Monash Univ, Cent Clin Sch & Alfred, Monash Alfred Psychiat Res Ctr, Melbourne, Vic 3004, Australia
来源：
PLOS ONE | 2015年 / 10卷 / 07期
关键词：
MOTOR CORTICAL EXCITABILITY; MAGNETIC STIMULATION; ELECTRICAL-STIMULATION; TACS; PERCEPTION; MODULATION; SAFETY; CORTEX;
D O I：
10.1371/journal.pone.0131779
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The aim is to investigate the effects of pulse duration (PD) on the modulatory effects of transcranial pulsed current (tPCS) on corticospinal excitability (CSE). CSE of the dominant primary motor cortex (M1) of right first dorsal interosseous muscle was assessed by motor evoked potentials, before, immediately, 10, 20 and 30 minutes after application of five experimental conditions: 1) anodal transcranial direct current stimulation (a-tDCS), 2) a-tPCS with 125 ms pulse duartion (a-tPCS(PD = 125)), 3) a-tPCS with 250 ms pulse duration (a-tPCS(PD = 250)), 4) a-tPCS with 500 ms pulse duration (a-tPCS(PD = 500)) and 5) sham a-tPCS. The total charges were kept constant in all experimental conditions except sham condition. Post-hoc comparisons indicated that a-tPCS(PD = 500) produced larger CSE compared to a-tPCS(PD = 125) (P<0.0001), a-tPCS(PD = 250) (P = 0.009) and a-tDCS (P = 0.008). Also, there was no significant difference between a-tPCS(PD = 250) and a-tDCS on CSE changes (P>0.05). All conditions except a-tPCS(PD = 125) showed a significant difference to the sham group (P<0.006). All participants tolerated the applied currents. It could be concluded that a-tPCS with a PD of 500ms induces largest CSE changes, however further studies are required to identify optimal values.
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页数：14
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