Activity of DBXX granules on anti-gastric ulcer and decreasing the side effect of chemotherapy in S180 tumor-bearing mice

Ethnopharmacological relevance: DBXX is a derived prescription from "Banxiaxiexin Tang" in "Shanghan Lun", the representative prescription to regulate spleen and stomach. Aim of the study: To determine the pharmacodynamics effects of DBXX granules on anti-ulcer and anti-side effect on digestive system induced by chemotherapeutic drugs. Materials and methods: Chronic gastric ulcer was induced by an injection of 100% glacial acetic acid into the submucosal layer of the glandular stomach, then the area of all ulcers was added together as the ulcer index and inhibition rate of ulcer was calculated. While S180 tumor-bearing mice were treated with cyclophosphamide as the chemotherapeutic drug, the weight of food-intake after chemotherapy, the loss body weight, tumor weight and spleen index were weighed and calculated. Results: In the gastric ulcer bearing mice, DBXX granules showed a dose-dependent reduction of ulcer at the dose 4.87 and 9.73 g/kg. In the S180 tumor-bearing mice, low dose of DBXX granules could significantly improve every investigated index compared with that of control group (p < 0.05). Conclusions: It proved that DBXX granules showed good healing effect on the chronic gastric ulcer mice and significant effect on decreasing the side effect of chemotherapy of S180 tumor-bearing mice. (C) 2011 Elsevier Ireland Ltd. All rights reserved.