Solalyratins A and B, new anti-inflammatory metabolites from Solanum lyratum

被引：31
作者：
Zhang, De-Wu [1 ,2 ]
Yang, Yan [2 ]
Yao, Fang [1 ]
Yu, Qun-Ying [1 ]
Dai, Sheng-Jun [1 ]
机构：
[1] Yantai Univ, Sch Pharmaceut Sci, Yantai 264005, Peoples R China
[2] Chinese Acad Med Sci, Inst Mat Med, Peking Union Med Coll, Beijing 100050, Peoples R China
来源：
JOURNAL OF NATURAL MEDICINES | 2012年 / 66卷 / 02期
关键词：
Solanum lyratum Thunb; Solanaceae; Solalyratins A; B; Anti-inflammatory activity; SESQUITERPENOIDS; ANTIOXIDANT;
D O I：
10.1007/s11418-011-0581-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new coumestan (solalyratin A, 1) and a novel cyclic eight-membered alpha,beta-unsaturated ketone (solalyratin B, 3), together with three known compounds, puerariafuran (2), coumestrol (4) and 9-hydroxy-2',2'-dimethylpyrano[5',6':2,3]-coumestan (5), were isolated from the whole plant of Solanum lyratum. Their structures were elucidated on the basis of spectroscopic analyses. In vitro, compounds 1-5 showed anti-inflammatory activities, with IC50 values in the range 6.3-9.1 mu M.
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收藏
页码：362 / 366
页数：5
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