Pulse-driven magnetoimpedance sensor detection of biomagnetic fields in musculatures with spontaneous electric activity

被引：16
作者：
Nakayama, Shinsuke [1 ]
Atsuta, Satoshi [1 ,3 ]
Shinmi, Takao [1 ]
Uchiyama, Tsuyoshi [2 ]
机构：
[1] Nagoya Univ, Grad Sch Med, Dept Cell Physiol, Nagoya, Aichi 4668550, Japan
[2] Nagoya Univ, Grad Sch Engn, Dept Elect, Nagoya, Aichi 4648603, Japan
[3] Fujidenolo, Technol Dev Div, Aichi 4850052, Japan
来源：
BIOSENSORS & BIOELECTRONICS | 2011年 / 27卷 / 01期
关键词：
Magnetoimpedance sensor; Body temperature; Spontaneous rhythm; Histogram; Power spectrum; PLURIPOTENT STEM-CELLS; SMOOTH-MUSCLE; VOLTAGE-CLAMP; IONIC CURRENTS; AMORPHOUS WIRE; ACTIVATION;
D O I：
10.1016/j.bios.2011.05.041
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
We measured biomagnetic fields in musculatures with spontaneous electric activity using a pulse-driven magnetoimpedance (PMI) sensor with the sensitivity improved toward a pico-Tesla (pT) level. Due to the sufficiently short operation interval of 1 mu s, this magnetic sensor enabled quasi-real time recordings of the magnetic field for biological electric activity. Isolated small musculatures from the guinea-pig stomach, taenia caeci, portal vein and urinary bladder were incubated in an organ bath at a body temperature. The improved PMI sensor mounted approximately 1 mm below the preparations detected oscillatory magnetic fields reflecting spontaneous electric activities of musculature preparations. In the taenia caeci, application of tetraethyl ammonium (TEA), a K+ channel blocker, significantly enhanced the magnetic activity estimated by histogram analysis. Also, in some musculature preparations, simultaneous measurements with electric activity revealed that the observed magnetic activities were attributed to biological electric activity. PMI technology is promising for applications in biology and medicine. (C) 2011 Elsevier B.V. All rights reserved.
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收藏
页码：34 / 39
页数：6
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