A quantitative analysis software tool for mass spectrometry-based proteomics

被引:0
|
作者
Park, Sung Kyu [1 ]
Venable, John D. [1 ]
Xu, Tao [1 ]
Yates, John R., III [1 ]
机构
[1] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92014 USA
关键词
D O I
10.1038/NMETH.1195
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
We describe Census, a quantitative software tool compatible with many labeling strategies as well as with label-free analyses, single-stage mass spectrometry (MS1) and tandem mass spectrometry (MS/MS) scans, and high-and low-resolution mass spectrometry data. Census uses robust algorithms to address poor-quality measurements and improve quantitative efficiency, and it can support several input file formats. We tested Census with stable-isotope labeling analyses as well as label-free analyses.
引用
收藏
页码:319 / 322
页数:4
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