Tetanus-diphtheria vaccination in adults: the long-term persistence of antibodies is not dependent on polyclonal B-cell activation and the defective response to diphtheria toxoid re-vaccination is associated to HLADRB1*01

被引：13

作者：

Ferlito, Claudia ^{[1
]}

Biselli, Roberto ^{[2
]}

Mariotti, Sabrina ^{[3
]}

Von Hunolstein, Christina ^{[3
]}

Teloni, Raffaela ^{[3
]}

Ralli, Luisa ^{[3
]}

Pinto, Antonella ^{[3
]}

Pisani, Giulio ^{[3
]}

Tirelli, Valentina ^{[3
]}

Biondo, Michela Ileen ^{[1
]}

Salerno, Gerardo ^{[1
]}

Bassi, Livia Andreasi ^{[1
]}

Lulli, Patrizia ^{[1
]}

Autore, Alberto ^{[4
]}

Scagliusi, Alessandro ^{[4
]}

Tomao, Enrico ^{[5
]}

Germano, Valentina ^{[1
]}

Diamanti, Andrea Picchianti ^{[1
]}

Caporuscio, Sara ^{[1
]}

Milanetti, Francesca ^{[1
]}

Salemi, Simonetta ^{[1
]}

Nisini, Roberto ^{[3
]}

D'Amelio, Raffaele ^{[1
]}

机构：

[1] Sapienza Univ Roma, Dipartimento Med Clin & Mol, Rome, Italy

[2] Aeronaut Mil Italiana, Comando Logist, Serv Sanitario, Rome, Italy

[3] Ist Super Sanita, Dipartimento Malattie Infett, Rome, Italy

[4] Aeronaut Mil Italiana, Ctr Sperimentale Volo, Comando Logist, Pratica Di Mare, Italy

[5] Aeronaut Mil Italiana, Capo Corpo Sanitario, Rome, Italy

来源：

VACCINE | 2018年 / 36卷 / 45期

关键词：

Vaccination; Anti-toxoid antibodies; HLA association; Duration of protection; Memory; IMMUNE-RESPONSES; MANDATORY VACCINATION; MILITARY PERSONNEL; GENE POLYMORPHISMS; RUBELLA VACCINE; ITALIANS BORN; PLASMA-CELL; FOLLOW-UP; MEMORY; CHILDREN;

D O I：

10.1016/j.vaccine.2018.09.041

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cellular and humoral immune responses to tetanus-diphtheria vaccine (Td) were assessed in human leukocyte antigen (HLA)-typed Italian military personnel who received multiple concomitant vaccines. Td-specific antibodies and T-lymphocytes were measured in individuals with one (group-1) and more than one (group-2) Td boosters. A third group (group-3), who received several vaccines, but not Td, was studied to verify the hypothesis of the polyclonal B-cell activation as mechanism for antibody persistence. The antibody response to Td toxoids was higher in group-1, who showed lower baseline antibody levels, than in group-2 subjects. The antibody response to tetanus was higher than to diphtheria toxoid in both groups. No correlation between antibody and cellular response, and no interference in the response to Td by co-administration of different vaccines were observed. HLA-DRB1*01 allele was detected at significant higher frequency in subjects unable to double the baseline anti-diphtheria antibody levels after the vaccination. Anti-tetanus and diphtheria antibodies half-lives were assessed and the long-lasting persistence above the threshold for protection (0.1 Itliml) was estimated in over 65 and 20 years, respectively. No significant increase of anti-diphtheria antibodies was observed in consequence of polyclonal B-cell activation. This study emphasizes the duration of Td vaccination-induced seroprotection, suggesting that re-vaccination should probably be performed at intervals longer than 10 years. No reciprocal interference by concomitantly administered vaccines has been observed. HLA-DRB1 *01 allele was significantly associated with anti-diphtheria defective response. Finally, this study does not confirm that anti-diphtheria antibody levels are maintained by polyclonal B-cell activation. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：6718 / 6725

页数：8

共 50 条

[1] IGE ANTIBODIES TO TETANUS TOXOID IN RELATION TO ATOPY
AALBERSE, RC
VANREE, R
DANNEMAN, A
WAHN, U
[J]. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1995, 107 (1-3) : 169 - 171
[2] Contributions of humoral and cellular immunity to vaccine-induced protection in humans
Amanna, Ian J.
Slifka, Mark K.
[J]. VIROLOGY, 2011, 411 (02) : 206 - 215
[3] Mechanisms that determine plasma cell lifespan and the duration of humoral immunity
Amanna, Ian J.
Slifka, Mark K.
[J]. IMMUNOLOGICAL REVIEWS, 2010, 236 : 125 - 138
[4] Maintenance of serological memory by polyclonal activation of human memory B cells
Bernasconi, NL
Traggiai, E
Lanzavecchia, A
[J]. SCIENCE, 2002, 298 (5601) : 2199 - 2202
[5] Immune Responses in US Military Personnel Who Received Meningococcal Conjugate Vaccine (MenACWY) Concomitantly with Other Vaccines Were Higher than in Personnel Who Received MenACWY Alone
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Romero-Steiner, Sandra
Rajam, Gowrisankar
Johnson, Scott E.
Milton, Andrea
Kim, Ellie
Choi, Lisa J.
Radin, Jennifer M.
Schmidt, Daniel S.
Carlone, George M.
Messonnier, Nancy
Faix, Dennis J.
[J]. CLINICAL AND VACCINE IMMUNOLOGY, 2016, 23 (08) : 672 - 680
[6] Distinct time effects of vaccination on long-term proliferative and IFN-γ-producing T cell memory to smallpox in humans
Combadiere, B
Boissonnas, A
Carcelain, G
Lefranc, E
Samri, A
Bricaire, F
Debre, P
Autran, B
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (11) : 1585 - 1593
[7] Reduced response to multiple vaccines sharing common protein epitopes that are administered simultaneously to infants
Dagan, R
Eskola, J
Leclerc, C
Leroy, O
[J]. INFECTION AND IMMUNITY, 1998, 66 (05) : 2093 - 2098
[8] TETANUS IMMUNITY AMONG ITALIANS BORN AFTER THE INTRODUCTION OF MANDATORY VACCINATION OF CHILDREN
DAMELIO, R
STROFFOLINI, T
WIRZ, M
BISELLI, R
MATRICARDI, PM
GENTILI, G
COLLOTTI, C
PASQUINI, P
[J]. VACCINE, 1993, 11 (09) : 935 - 936
[9] Vaccination of human subjects expands both specific and bystander memory T cells but antibody production remains vaccine specific
Di Genova, G
Roddick, J
McNicholl, F
Stevenson, FK
[J]. BLOOD, 2006, 107 (07) : 2806 - 2813
[10] Maternal antibodies and infant immune responses to vaccines
Edwards, Kathryn M.
[J]. VACCINE, 2015, 33 (47) : 6469 - 6472

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