Synthesis and antimicrobial activity of new pyridine derivatives-I

被引：67

作者：

Patel, Navin B. ^{[1
]}

Agravat, Suresh N. ^{[1
]}

Shaikh, Faiyazalam M. ^{[1
]}

机构：

[1] Veer Narmad S Gujarat Univ, Dept Chem, Surat 395007, Gujarat, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2011年 / 20卷 / 07期

关键词：

2-Aminobenzothiazoles; 2-Chloropyridine-3-carboxylic acid; Piperazines; Antimicrobial activity; ANTIBACTERIAL ACTIVITY; POTENT;

D O I：

10.1007/s00044-010-9440-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

2-Amino substituted benzothiazoles 2a-l and 2-chloropyridine-3-carboxylic acid 3 were used to prepare 2-[N-(substitutedbenzothiazolyl)amino]pyridine-3-carboxylic acids (4a-l) in 2-ethoxy ethanol. Acid chlorides (5a-l) were condensed with 2-hydroxyethyl piperazine (6) and 2,3-dichloropiperazine (7) to prepare amide derivatives 2-[N-(substituted benzothiazolyl)amino]pyridin-3-yl(4-(2-hydroxyethyl)piperazin-1-yl)methanones (8a-l) and 2-[N-(substituted benzothiazolyl) amino]pyridin-3-yl(2,3-dichloropiperazine-1-yl)methanones (9a-l), respectively. The structures of new compounds have been established on the basis of elemental analysis and spectral (IR, H-1 NMR, and Mass spectra) studies. The in vitro antimicrobial activity was screened for all the synthesized compounds. Variable and modest activity were observed against the investigated strains of bacteria and fungi.

引用

页码：1033 / 1041

页数：9

共 20 条

[1]

Aanandhi V, 2008, ARKIVOC, P187

[2]

Al-Soud Yaseen A., 2007, Acta Pharmaceutica (Zagreb), V57, P379, DOI 10.2478/v10007-007-0031-7

[3] Synthesis and in vitro antiproliferative activity of new benzothiazole derivatives [J].

Al-Soud, Yaseen A. ;

Al-Sa'doni, Haitham H. ;

Saeed, Bahjat ;

Jaber, Ihsan H. ;

Beni-Khalid, Mohammad O. ;

Al-Masoudi, Najim A. ;

Abdul-Kadir, Tahsin ;

La Colla, Paolo ;

Busonera, Bernardetta ;

Sanna, Tiziana ;

Loddo, Roberta .

ARKIVOC, 2008, :225-238

[4]

Barry A., 1976, The Antimicrobial Susceptibility Test: Principle and Practices

[5] Synthesis of novel 3-[5-ethyl-2-(2-phenoxy-ethyl)pyridin]-5-substituted isoxazoline libraries via 1,3-dipolar cycloaddition and evaluation of antimicrobial activities [J].

Gaonkar, S. L. ;

Rai, K. M. Lokanatha ;

Prabhuswamy, B. .

MEDICINAL CHEMISTRY RESEARCH, 2007, 15 (7-8) :407-417

[6]

JAVIER G, 1986, HETEROCYCLES, V24, P87

[7] SYNTHESIS OF SOME NEW 3-(2'-BENZOTHIAZOLYL)-4(3H)-QUINAZOLINONES AS ANTIFUNGAL AGENTS [J].

LAKHAN, R ;

RAI, BJ .

JOURNAL OF CHEMICAL AND ENGINEERING DATA, 1986, 31 (04) :501-502

[8] Synthesis and antibacterial activity of new N-[2-(thiophen-3-yl)ethyl] piperazinyl quinolones [J].

Letafat, Bahram ;

Emami, Saeed ;

Mohammadhosseini, Negar ;

Faramarzi, Mohammad Ali ;

Samadi, Nasrin ;

Shafiee, Abbas ;

Foroumadi, Alireza .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2007, 55 (06) :894-898

[9] Antifungal and antimycobacterial activity of new N1-[1-aryl-2-(1H-imidazol-1-yl and 1H-1,2,4-triazol-1-yl)-ethylidene]-pyridine-2-carboxamidrazone derivatives:: a combined experimental and computational approach [J].

Mamolo, MG ;

Zampieri, D ;

Falagiani, V ;

Vio, L ;

Fermeglia, M ;

Ferrone, M ;

Pricl, S ;

Banfi, E ;

Scialino, G .

ARKIVOC, 2004, :231-250

[10] Antitumor benzothiazoles. 26. 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines [J].

Mortimer, CG ;

Wells, G ;

Crochard, JP ;

Stone, EL ;

Bradshaw, TD ;

Stevens, MFG ;

Westwell, AD .

JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (01) :179-185

← 1 2 →