Serum carboxy-terminal propeptide of type I procollagen (PIP) is a marker of diastolic dysfunction in patients with early type 2 diabetes mellitus

被引：39

作者：

Ihm, Sang-Hyun ^{[1
]}

Youn, Ho-Joong ^{[1
]}

Shin, Dong-Il ^{[1
]}

Jang, Sung-Won ^{[1
]}

Park, Chul-Soo ^{[1
]}

Kim, Pum Joon ^{[1
]}

Kim, Hee-Yeol ^{[1
]}

Chang, Kiyuk ^{[1
]}

Seung, Ki-Bae ^{[1
]}

Kim, Jae-Hyung ^{[1
]}

Choi, Kyu-Bo ^{[1
]}

机构：

[1] Catholic Univ Korea, Dept Internal Med, Coll Med, St Marys Hosp, Seoul 150713, South Korea

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2007年 / 122卷 / 03期

关键词：

diabetes; procollagen; myocardial fibrosis; echocardiography; diastolic function;

D O I：

10.1016/j.ijcard.2007.07.057

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study was designed to investigate whether the serum concentration of the carboxy-terminal propeptide of procollagen type I (PIP), a marker of myocardial fibrosis, is related to changes of the ventricular filling dynamics in patients with early type 2 diabetes mellitus (T2DM). The T2DM group had lower mitral and tricuspid E/A ratios than the control group. Serum PIP was higher in patients with T2DM than in controls (131.1 +/-\ 45.6 vs. 109.3 +/- 32.5 ng/mL, p=0.039). A-Ar, an estimate of passive diastolic function, was inversely related to serum PIP levels in T2DM ( r=-0.42, p=0.03). These results show a relation between LV diastolic function and serum PIP levels in early T2DM. (C) 2007 Published by Elsevier Ireland Ltd.

引用

页码：E36 / E38

页数：3

共 12 条

[1] DIABETIC CARDIOMYOPATHY - A UNIQUE ENTITY OR A COMPLICATION OF CORONARY-ARTERY DISEASE [J].

BELL, DSH .

DIABETES CARE, 1995, 18 (05) :708-714

[2] Oxidative stress and fibrosis in incipient myocardial dysfunction in type 2 diabetic patients [J].

González-Vílchez, F ;

Ayuela, J ;

Ares, M ;

Pi, J ;

Castillo, L ;

Martín-Durán, R .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2005, 101 (01) :53-58

[3] Transforming growth factor β in hypertensives with cardiorenal damage [J].

Laviades, C ;

Varo, N ;

Díez, J .

HYPERTENSION, 2000, 36 (04) :517-522

[4] Myocardial collagen turnover in hypertrophic cardiomyopathy [J].

Lombardi, R ;

Betocchi, S ;

Losi, MA ;

Tocchetti, CG ;

Aversa, M ;

Miranda, M ;

D'Alessandro, G ;

Cacace, A ;

Ciampi, Q ;

Chiariello, M .

CIRCULATION, 2003, 108 (12) :1455-1460

[5] Biochemical assessment of myocardial fibrosis in hypertensive heart disease [J].

López, B ;

González, A ;

Varo, N ;

Laviades, C ;

Querejeta, R ;

Díez, J .

HYPERTENSION, 2001, 38 (05) :1222-1226

[6] Usefulness of serum carboxy-terminal propeptide of procollagen type I in assessment of the cardioreparative ability of antihypertensive treatment in hypertensive patients [J].

López, B ;

Querejeta, R ;

Varo, N ;

González, A ;

Larman, M ;

Ubago, JLM ;

Díez, J .

CIRCULATION, 2001, 104 (03) :286-291

[7] CLINICALLY UNRECOGNIZED VENTRICULAR DYSFUNCTION IN YOUNG DIABETIC-PATIENTS [J].

MILDENBERGER, RR ;

BARSHLOMO, B ;

DRUCK, MN ;

JABLONSKY, G ;

MORCH, JE ;

HILTON, JD ;

KENSHOLE, AB ;

FORBATH, N ;

MCLAUGHLIN, PR .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1984, 4 (02) :234-238

[8] Alteration in left ventricular diastolic filling and accumulation of myocardial collagen at insulin-resistant prediabetic stage of a type II diabetic rat model [J].

Mizushige, K ;

Yao, L ;

Noma, T ;

Kiyomoto, H ;

Yu, Y ;

Hosomi, N ;

Ohmori, K ;

Matsuo, H .

CIRCULATION, 2000, 101 (08) :899-907

[9] PREVALENCE AND SIGNIFICANCE OF LEFT-VENTRICULAR FILLING ABNORMALITIES DETERMINED BY DOPPLER ECHOCARDIOGRAPHY IN YOUNG TYPE-I (INSULIN-DEPENDENT) DIABETIC-PATIENTS [J].

PAILLOLE, C ;

DAHAN, M ;

PAYCHA, F ;

SOLAL, AC ;

PASSA, P ;

GOURGON, R .

AMERICAN JOURNAL OF CARDIOLOGY, 1989, 64 (16) :1010-1016

[10]

Querejeta R, 2000, CIRCULATION, V101, P1729

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