Sexual determination in zebrafish

被引：37

作者：

Aharon, Devora ^{[1
]}

Marlow, Florence L. ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Cell Dev & Regenerat Biol, One Gustave L Levy,Pl Box 1020, New York, NY 10029 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2022年 / 79卷 / 01期

关键词：

Sex determination; RNA binding protein; Ovary; Testis; Genetics; PRIMORDIAL GERM-CELLS; TRANSCRIPTION FACTOR FOXL2; POLYCYSTIC-OVARY-SYNDROME; MULLERIAN HORMONE AMH; STEM-CELLS; EXPRESSION PATTERN; GONAD DEVELOPMENT; OOCYTE APOPTOSIS; SELF-RENEWAL; DEAD-END;

D O I：

10.1007/s00018-021-04066-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Zebrafish have emerged as a major model organism to study vertebrate reproduction due to their high fecundity and external development of eggs and embryos. The mechanisms through which zebrafish determine their sex have come under extensive investigation, as they lack a definite sex-determining chromosome and appear to have a highly complex method of sex determination. Single-gene mutagenesis has been employed to isolate the function of genes that determine zebrafish sex and regulate sex-specific differentiation, and to explore the interactions of genes that promote female or male sexual fate. In this review, we focus on recent advances in understanding of the mechanisms, including genetic and environmental factors, governing zebrafish sex development with comparisons to gene functions in other species to highlight conserved and potentially species-specific mechanisms for specifying and maintaining sexual fate.

引用

页数：19