Overlapping clusters of gray matter deficits in paranoid schizophrenia and psychotic bipolar mania with family history

被引：33
作者：
Cui, Liqian [1 ,2 ]
Li, Mingli [1 ,2 ]
Deng, Wei [1 ,2 ]
Guo, Wanjun [1 ,2 ]
Ma, Xiaohong [1 ,2 ]
Huang, Chaohua [1 ,2 ]
Jiang, Lijun [1 ,2 ]
Wang, Yingcheng [1 ,2 ]
Collier, David A. [5 ]
Gong, Qiyong [3 ]
Li, Tao [1 ,2 ,4 ,5 ]
机构：
[1] Sichuan Univ, Dept Psychiat, State Key Lab Biotherapy, W China Hosp, Chengdu 610041, Peoples R China
[2] Sichuan Univ, Psychiat Lab, State Key Lab Biotherapy, W China Hosp, Chengdu 610041, Peoples R China
[3] Sichuan Univ, W China Hosp, MRI Ctr, Chengdu 610041, Peoples R China
[4] Kings Coll London, Inst Psychiat, Dept Psychiat & Psychol Med, London WC2R 2LS, England
[5] Kings Coll London, Inst Psychiat, MRC Social Genet & Dev Psychiat Ctr, London WC2R 2LS, England
来源：
NEUROSCIENCE LETTERS | 2011年 / 489卷 / 02期
关键词：
Schizophrenia; Bipolar disorder; Voxel-based morphometry; Magnetic resonance imaging; VOXEL-BASED MORPHOMETRY; INFERIOR PARIETAL LOBULE; AUDITORY HALLUCINATIONS; DISORDER; METAANALYSIS; ABNORMALITIES; VOLUME; ACTIVATION; ANATOMY; SCALE;
D O I：
10.1016/j.neulet.2010.11.073
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The purpose of this study was to assess volumetric abnormalities of gray matter throughout the entire brain in patients with paranoid schizophrenia or with bipolar mania compared with control groups. We obtained weighted 3D T1 magnetic resonance images from 23 patients with paranoid schizophrenia, 24 patients with psychotic bipolar mania, and 36 healthy controls. Gray matter volume differences were assessed using optimized volumetric voxel-based morphometry (VBM). Both paranoid schizophrenia and bipolar mania group showed reduction of gray matter volume in the superior temporal gyrus (STG) (Brodmann Area, BA 22 areas), and the inferior parietal lobule, and enlargement of putamen, although different sides of the inferior parietal lobule and putamen were affected in the groups. Our findings showed the presence of overlapping clusters of gray matter deficits in paranoid-type schizophrenia and psychotic bipolar mania. The overlap in gray matter pathology between the two disorders may be attributed to risk factors common to both disorders. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：94 / 98
页数：5
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