Improving cancer immunotherapy by targeting IL-1

被引：6

作者：

Xiao, Zhilan ^{[1
]}

Singh, Shubhra ^{[2
]}

Singh, Manisha ^{[2
]}

机构：

[1] Indiana Univ Sch Med, Dept Internal Med, Indianapolis, IN 46202 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Genom Med, Houston, TX 77054 USA

来源：

ONCOIMMUNOLOGY | 2021年 / 10卷 / 01期

关键词：

Inflammation; IL-1; cancer; immunotherapy; INTERLEUKIN-1; ACIDOSIS; CELLS;

D O I：

10.1080/2162402X.2021.2008111

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Interleukin-1 (IL-1) is an inflammatory cytokine associated with tumor invasiveness and metastasis. We recently found that baseline IL-1 in melanomas promoted resistance to immunotherapy by creating an immunosuppressive tumor microenvironment and that IL-1 produced in response to CD40 agonist also induced resistance to therapy. Here, we discuss how naturally occurring and immunotherapy-induced IL-1 in tumors causes immune suppression and resistance to immunotherapy, and we discuss targeting the IL-1 pathway to enhance the efficacy of immunotherapy.

引用

页数：3

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