Improving cancer immunotherapy by targeting IL-1

被引：7

作者：

Xiao, Zhilan ^{[1
]}

Singh, Shubhra ^{[2
]}

Singh, Manisha ^{[2
]}

机构：

[1] Indiana Univ Sch Med, Dept Internal Med, Indianapolis, IN 46202 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Genom Med, Houston, TX 77054 USA

来源：

ONCOIMMUNOLOGY | 2021年 / 10卷 / 01期

关键词：

Inflammation; IL-1; cancer; immunotherapy; INTERLEUKIN-1; ACIDOSIS; CELLS;

D O I：

10.1080/2162402X.2021.2008111

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Interleukin-1 (IL-1) is an inflammatory cytokine associated with tumor invasiveness and metastasis. We recently found that baseline IL-1 in melanomas promoted resistance to immunotherapy by creating an immunosuppressive tumor microenvironment and that IL-1 produced in response to CD40 agonist also induced resistance to therapy. Here, we discuss how naturally occurring and immunotherapy-induced IL-1 in tumors causes immune suppression and resistance to immunotherapy, and we discuss targeting the IL-1 pathway to enhance the efficacy of immunotherapy.

引用

页数：3

共 12 条

[1] Blocking IL1 Beta Promotes Tumor Regression and Remodeling of the Myeloid Compartment in a Renal Cell Carcinoma Model: Multidimensional Analyses [J].

Aggen, David H. ;

Ager, Casey R. ;

Obradovic, Aleksandar Z. ;

Chowdhury, Nivedita ;

Ghasemzadeh, Ali ;

Mao, Wendy ;

Chaimowitz, Matthew G. ;

Lopez-Bujanda, Zoila A. ;

Spina, Catherine S. ;

Hawley, Jessica E. ;

Dallos, Matthew C. ;

Zhang, Cheng ;

Wang, Vinson ;

Li, Hu ;

Guo, Xinzheng, V ;

Drake, Charles G. .

CLINICAL CANCER RESEARCH, 2021, 27 (02) :608-621

[2] Interleukin-1 receptor antagonist: Role in biology [J].

Arend, WP ;

Malyak, M ;

Guthridge, CJ ;

Gabay, C .

ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 :27-55

[3] IL-1α Processing, Signaling and Its Role in Cancer Progression [J].

Chiu, Jing Wen ;

Binte Hanafi, Zuhairah ;

Chew, Lionel Chin Yong ;

Mei, Yu ;

Liu, Haiyan .

CELLS, 2021, 10 (01) :1-19

[4] Proinflammatory cytokines [J].

Dinarello, CA .

CHEST, 2000, 118 (02) :503-508

[5] Acidosis Drives Damage-associated Molecular Pattern (DAMP)-induced Interleukin-1 Secretion via a Caspase-1-independent Pathway [J].

Edye, Michelle E. ;

Lopez-Castejon, Gloria ;

Allan, Stuart M. ;

Brough, David .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (42) :30485-30494

[6] Elevated chronic inflammatory factors and myeloid-derived suppressor cells indicate poor prognosis in advanced melanoma patients [J].

Jiang, Huanhuan ;

Gebhardt, Christoffer ;

Umansky, Ludmila ;

Beckhove, Philipp ;

Schulze, Torsten J. ;

Utikal, Jochen ;

Umansky, Viktor .

INTERNATIONAL JOURNAL OF CANCER, 2015, 136 (10) :2352-2360

[7] Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti-PD-1 for tumor abrogation [J].

Kaplanov, Irena ;

Carmi, Yaron ;

Kornetsky, Rachel ;

Shemesh, Avishai ;

Shurin, Galina V. ;

Shurin, Michael R. ;

Dinarello, Charles A. ;

Voronov, Elena ;

Apte, Ron N. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (04) :1361-1369

[8] Constitutive Aberrant Endogenous Interleukin-1 Facilitates Inflammation and Growth in Human Melanoma [J].

Qin, Yong ;

Ekmekcioglu, Suhendan ;

Liu, Ping ;

Duncan, Lyn M. ;

Lizee, Gregory ;

Poindexter, Nancy ;

Grimm, Elizabeth A. .

MOLECULAR CANCER RESEARCH, 2011, 9 (11) :1537-1550

[9] Extracellular Acidosis Is a Novel Danger Signal Alerting Innate Immunity via the NLRP3 Inflammasome [J].

Rajamaki, Kristiina ;

Nordstrom, Tommy ;

Nurmi, Katariina ;

Akerman, Karl E. O. ;

Kovanen, Petri T. ;

Oorni, Katariina ;

Eklund, Kari K. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (19) :13410-13419

[10] Ligation of CD40 activates interleukin 1 beta-converting enzyme (caspase-1) activity in vascular smooth muscle and endothelial cells and promotes elaboration of active interleukin 1 beta [J].

Schonbeck, U ;

Mach, F ;

Bonnefoy, JY ;

Loppnow, H ;

Flad, HD ;

Libby, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (31) :19569-19574

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