Improving cancer immunotherapy by targeting IL-1

被引：6
|
作者：
Xiao, Zhilan [1 ]
Singh, Shubhra [2 ]
Singh, Manisha [2 ]
机构：
[1] Indiana Univ Sch Med, Dept Internal Med, Indianapolis, IN 46202 USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Genom Med, Houston, TX 77054 USA
来源：
ONCOIMMUNOLOGY | 2021年 / 10卷 / 01期
关键词：
Inflammation; IL-1; cancer; immunotherapy; INTERLEUKIN-1; ACIDOSIS; CELLS;
D O I：
10.1080/2162402X.2021.2008111
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Interleukin-1 (IL-1) is an inflammatory cytokine associated with tumor invasiveness and metastasis. We recently found that baseline IL-1 in melanomas promoted resistance to immunotherapy by creating an immunosuppressive tumor microenvironment and that IL-1 produced in response to CD40 agonist also induced resistance to therapy. Here, we discuss how naturally occurring and immunotherapy-induced IL-1 in tumors causes immune suppression and resistance to immunotherapy, and we discuss targeting the IL-1 pathway to enhance the efficacy of immunotherapy.
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收藏
页数：3
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