Two new paeciloxocins from a mangrove endophytic fungus Paecilomyces sp.

被引：23

作者：

Wen, Lu ^{[1
]}

Chen, Gang ^{[1
]}

She, Zhigang ^{[2
]}

Yan, Chunyan ^{[1
]}

Cai, Juanni ^{[1
]}

Mu, Lei ^{[1
]}

机构：

[1] Guangdong Pharmaceut Univ, Coll Pharm, Guangzhou 510006, Guangdong, Peoples R China

[2] Sun Yat Sen Zhongshan Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China

来源：

RUSSIAN CHEMICAL BULLETIN | 2010年 / 59卷 / 08期

基金：

中国国家自然科学基金;

关键词：

mangroves; endophytic fungus; metabolites; paeciloxocins; cytotoxicity; SOUTH CHINA SEA; XYLARIA SP NUMBER-2508; NATURAL-PRODUCTS; METABOLITES; DERIVATIVES; COAST;

D O I：

10.1007/s11172-010-0290-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Paeciloxocins A and B (2-(1-hydroxy-3-methylbutyl)- and 2-(1-acetoxy-3-methylbutyl)- 11-hydroxy-9-methyl-1-methoxy-5H,7H-dibenzo[b,g]-1,5-dioxocin-5-ones), viz., two new metabolites, were isolated from the mangrove fungus Paecilomyces sp. collected from the Taiwan Strait. Their structures were elucidated by spectral methods. Paeciloxocin A exhibited strong cytotoxicity against the hepG2 cell line.

引用

页码：1656 / 1659

页数：4

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