Research Progress on the Relationship between Atherosclerosis and Inflammation

被引：716
作者：
Zhu, Yuhua [1 ]
Xian, Xuemei [1 ]
Wang, Zhenzhen [1 ]
Bi, Yingchao [1 ]
Chen, Quangang [1 ]
Han, Xufeng [1 ]
Tang, Daoquan [1 ]
Chen, Renjin [1 ]
机构：
[1] Xuzhou Med Univ, Lab Anim Ctr, Xuzhou 221004, Jiangsu, Peoples R China
来源：
BIOMOLECULES | 2018年 / 8卷 / 03期
基金：
中国博士后科学基金;
关键词：
atherosclerosis; inflammation; anti-inflammatory therapy; C-REACTIVE PROTEIN; HMG-COA REDUCTASE; FOAM-CELL-FORMATION; TOLL-LIKE RECEPTORS; ADHESION MOLECULES; PLAQUE PROGRESSION; ENDOTHELIAL-CELLS; TISSUE INHIBITOR; MACROPHAGE; EXPRESSION;
D O I：
10.3390/biom8030080
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Atherosclerosis is a chronic inflammatory disease; unstable atherosclerotic plaque rupture, vascular stenosis, or occlusion caused by platelet aggregation and thrombosis lead to acute cardiovascular disease. Atherosclerosis-related inflammation is mediated by proinflammatory cytokines, inflammatory signaling pathways, bioactive lipids, and adhesion molecules. This review discusses the effects of inflammation and the systemic inflammatory signaling pathway on atherosclerosis, the role of related signaling pathways in inflammation, the formation of atherosclerosis plaques, and the prospects of treating atherosclerosis by inhibiting inflammation.
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页数：11
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