Expression of bcl-2 in uveal malignant melanoma

被引：0
|
作者：
Jay, V [1 ]
Yi, Q [1 ]
Hunter, WS [1 ]
Zielenska, M [1 ]
机构：
[1] UNIV TORONTO,DEPT OPHTHALMOL,TORONTO,ON M5S 1A1,CANADA
来源：
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE | 1996年 / 120卷 / 05期
关键词：
D O I：
暂无
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Objective.-To evaluate the expression of the bcl-2 proto-oncogene in uveal malignant melanomas. Case Material.-We studied 20 uveal malignant melanomas (19 choroidal and 1 ciliary body) by immunohistochemistry with the bcl-2 oncoprotein monoclonal antibody and the cell proliferation marker, MIB-1. Results.-Expression of bcl-2 was found in 100% of cases and was not correlated with the histologic subtype of melanoma or the MIB-1 proliferative index. Normal choroidal melanocytes were negative for bcl-2. Conclusion.-Our results suggest that altered expression of bcl-2 is common in uveal melanomas and is not related to histologic grade.
引用
收藏
页码：497 / 498
页数：2
相关论文
共 50 条
  • [21] Small interfering RNA targeting Bcl-2 sensitizes malignant melanoma
    Wacheck, V
    Losert, D
    Günsberg, P
    Vornlocher, HP
    Hadwiger, P
    Geick, A
    Pehamberger, H
    Müller, M
    Jansen, B
    OLIGONUCLEOTIDES, 2003, 13 (05) : 393 - 400
  • [22] Expression of HSP 90, PTEN and Bcl-2 in conjunctival melanoma
    Westekemper, Henrike
    Karimi, Sara
    Suesskind, Daniela
    Anastassiou, Gerasimos
    Freistuehler, Michael
    Steuhl, Klaus-Peter
    Bornfeld, Norbert
    Schmid, Kurt-Werner
    Grabellus, Florian
    BRITISH JOURNAL OF OPHTHALMOLOGY, 2011, 95 (06) : 853 - 858
  • [23] Expression of Bcl-2 family members in malignant pleural mesothelioma
    O'Kane, Sara L.
    Pound, Rachelle J.
    Campbell, Anne
    Chaudhuri, Nilanjan
    Lind, Michael J.
    Cawkwell, Lynn
    ACTA ONCOLOGICA, 2006, 45 (04) : 449 - 453
  • [24] Bcl-2, c-myc and p53 immunohistochemical analysis in uveal melanoma
    Blasi, MA
    Rota, R
    Serra, MG
    Calvisi, G
    Balestrazzi, E
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1996, 37 (03) : 1107 - 1107
  • [25] Targeting Bcl-2/Bcl-XL Induces Antitumor Activity in Uveal Melanoma Patient-Derived Xenografts
    Nemati, Fariba
    de Montrion, Catherine
    Lang, Guillaume
    Kraus-Berthier, Laurence
    Carita, Guillaume
    Sastre-Garau, Xavier
    Berniard, Aurelie
    Vallerand, David
    Geneste, Olivier
    de Plater, Ludmilla
    Pierre, Alain
    Lockhart, Brian
    Desjardins, Laurence
    Piperno-Neumann, Sophie
    Depil, Stephane
    Decaudin, Didier
    PLOS ONE, 2014, 9 (01):
  • [26] PTEN expression in melanoma: Relationship with patient survival, Bcl-2 expression, and proliferation
    Mikhail, M
    Velazquez, E
    Shapiro, R
    Berman, R
    Pavlick, A
    Sorhaindo, L
    Spira, J
    Mir, C
    Panageas, KS
    Polsky, D
    Osman, I
    CLINICAL CANCER RESEARCH, 2005, 11 (14) : 5153 - 5157
  • [27] Small interfering RNA targeting Bcl-2 sensitize malignant melanoma.
    Wacheck, V
    Losert, D
    Strommer, S
    Vornlocher, HP
    Hadwiger, P
    Geick, A
    Pehamberger, H
    Jansen, B
    CLINICAL CANCER RESEARCH, 2003, 9 (16) : 6233S - 6233S
  • [28] Significance of PCNA, bcl-2, and DNA ploidy in prognosis of cutaneous malignant melanoma
    Jukic, DM
    Ruiz, JE
    Babic, D
    Krizanac, S
    LABORATORY INVESTIGATION, 1999, 79 (01) : 58A - 58A
  • [29] The expression of bcl-2 and bcl-6 protein in normal and malignant transitional epithelium
    Lin, ZH
    Kim, H
    Park, H
    Kim, Y
    Cheon, J
    Kim, I
    UROLOGICAL RESEARCH, 2003, 31 (04): : 272 - 275
  • [30] The expression of bcl-2 and bcl-6 protein in normal and malignant transitional epithelium
    Zhenhua Lin
    Hankyeom Kim
    Hongseok Park
    Youngsik Kim
    Jun Cheon
    Insun Kim
    Urological Research, 2003, 31 : 272 - 275
12345