Expression of bcl-2 in uveal malignant melanoma

被引：0
|
作者：
Jay, V [1 ]
Yi, Q [1 ]
Hunter, WS [1 ]
Zielenska, M [1 ]
机构：
[1] UNIV TORONTO,DEPT OPHTHALMOL,TORONTO,ON M5S 1A1,CANADA
来源：
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE | 1996年 / 120卷 / 05期
关键词：
D O I：
暂无
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Objective.-To evaluate the expression of the bcl-2 proto-oncogene in uveal malignant melanomas. Case Material.-We studied 20 uveal malignant melanomas (19 choroidal and 1 ciliary body) by immunohistochemistry with the bcl-2 oncoprotein monoclonal antibody and the cell proliferation marker, MIB-1. Results.-Expression of bcl-2 was found in 100% of cases and was not correlated with the histologic subtype of melanoma or the MIB-1 proliferative index. Normal choroidal melanocytes were negative for bcl-2. Conclusion.-Our results suggest that altered expression of bcl-2 is common in uveal melanomas and is not related to histologic grade.
引用
收藏
页码：497 / 498
页数：2
相关论文
共 50 条
  • [1] Bcl-2 expression in primary uveal melanoma
    Sulkowska, M
    Famulski, W
    Bakunowicz-Lazarczyk, A
    Chyczewski, L
    Sulkowski, S
    TUMORI, 2001, 87 (01) : 54 - 57
  • [2] Bcl-2 in uveal melanoma: Immunohistochemical study
    Capeans, MC
    Abraldes, M
    Santos, L
    GarciaCaballero, T
    RodriguezPereira, C
    SanchezSalorio, M
    Forteza, J
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1996, 37 (03) : 1106 - 1106
  • [3] Bcl-2 expression in malignant melanoma and its prognostic significance
    Grover, R
    Wilson, GD
    EUROPEAN JOURNAL OF SURGICAL ONCOLOGY, 1996, 22 (04): : 347 - 349
  • [4] BCL-2 AND P-53 EXPRESSION IN MALIGNANT-MELANOMA
    DUVAL, J
    MALHOTRA, R
    SAVAS, L
    KUMAR, W
    WODA, B
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1994, 102 (04) : 577 - 577
  • [5] Chemosensitization of malignant melanoma by Bcl-2 siRNA
    Wacheck, V
    Losert, D
    Strommer, S
    Jansen, B
    Pehamberger, H
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2004, 123 (02)
  • [6] BCL-2 EXPRESSION IN CHOROIDAL MELANOMA
    ABRALDES, M
    GARCIACABALLERO, T
    SANTOS, L
    PEREIRA, CR
    CAPEANS, C
    SALORIO, MS
    FORTEZA, J
    VISION RESEARCH, 1995, 35 : 2253 - 2253
  • [7] Bcl-2 and bcl-2 family genes expression in metastatic cutaneous melanoma
    Okroujnov, I
    Angeletti, S
    Garcia-Foncillas, J
    Jimenez, E
    Andion, E
    Martinez, MJ
    EUROPEAN JOURNAL OF CANCER, 1999, 35 : S370 - S370
  • [8] Antiapoptotic bcl-2 and bcl-xL in advanced malignant melanoma
    U. Leiter
    R. M. Schmid
    P. Kaskel
    R. U. Peter
    G. Krähn
    Archives of Dermatological Research, 2000, 292 : 225 - 232
  • [9] Antiapoptotic bcl-2 and bcl-xL in advanced malignant melanoma
    Leiter, U
    Schmid, RM
    Kaskel, P
    Peter, RU
    Krähn, G
    ARCHIVES OF DERMATOLOGICAL RESEARCH, 2000, 292 (05) : 225 - 232
  • [10] Expression and Function of Bcl-2 Proteins in Melanoma
    Eberle, Juergen
    Hossini, Amir M.
    CURRENT GENOMICS, 2008, 9 (06) : 409 - 419
12345