The Role of Androgens in Metabolism, Obesity, and Diabetes in Males and Females

被引：199

作者：

Navarro, Guadalupe ^{[1
]}

Allard, Camille ^{[2
]}

Xu, Weiwei ^{[2
]}

Mauvais-Jarvis, Franck ^{[2
]}

机构：

[1] Stanford Univ, Dept Med, Div Endocrinol & Metab, Stanford, CA 94305 USA

[2] Tulane Univ, Sch Med, Hlth Sci Ctr, Sect Endocrinol & Metab, New Orleans, LA 70112 USA

来源：

OBESITY | 2015年 / 23卷 / 04期

基金：

美国国家卫生研究院;

关键词：

POLYCYSTIC-OVARY-SYNDROME; HORMONE-BINDING GLOBULIN; ENDOGENOUS SEX-HORMONES; BETA-CELL FUNCTION; INSULIN SENSITIVITY; DEPRIVATION THERAPY; PROSTATE-CANCER; HEPATIC STEATOSIS; BODY-COMPOSITION; MALE-MICE;

D O I：

10.1002/oby.21033

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

ObjectiveIn men, androgen deprivation contributes to the development of metabolic syndrome and type 2 diabetes (T2D). In women, androgen excess predisposes to insulin resistance and T2D. There is a bidirectional modulation of glucose homeostasis by androgens in males and females that is analyzed in this review. MethodsWe reviewed the literature in both rodents and humans on the role of androgens and the androgen receptor (AR) in the control of glucose and energy metabolism in health, obesity, and T2D. ResultsSex-specific activation of AR in the hypothalamus, skeletal muscle, liver, adipose tissue, and pancreatic islet -cells accounts for maintenance or disruption in energy metabolism and glucose homeostasis. ConclusionsWe argue that AR is a target to prevent androgen-related metabolic disorders.

引用

页码：713 / 719

页数：7

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