Synthesis of warhead containing scaffolds on irreversible 7H-pyrrolo[2,3-d]pyrimidine EGFR T790M inhibitors

被引：0

作者：

Matthews, Jean ^{[1
]}

Kephart, Susan ^{[1
]}

Zhou, Ru ^{[1
]}

Pairish, Mason ^{[1
]}

Behenna, Douglas ^{[1
]}

Cho-Schultz, Sujin ^{[1
]}

Nair, Sajiv ^{[1
]}

Ornelas, Martha ^{[1
]}

Orr, Suvi ^{[1
]}

Richter, Daniel ^{[1
]}

Shen, Hong ^{[1
]}

Sutton, Scott ^{[1
]}

Khanh Tran ^{[1
]}

机构：

[1] Pfizer R&D La Jolla, Oncol Chem Synth, La Jolla, CA USA

来源：

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 249卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

322

引用

页数：1

共 50 条

[1] Discovery and development of a series of irreversible EGFR_T790M 7H-pyrrolo[2,3-d]pyrimidine inhibitors with high selectivity over EGFR wild type
Planken, Simon
Nair, Sajiv
Kath, John
Lafontaine, Jennifer
Weinrich, Scott
Cheng, Henry
Sutton, Scott
Johnson, Theodore
Zientek, Michael
Nagata, Asako
Gajiwala, Ketan
Solowiej, Jim
Murray, Brion
Yin, Min-Jean
Hemkens, Michelle
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2015, 249
[2] Synthesis of 2-aminoaryl-4-alkoxy-5-heteroaryl-7H-pyrrolo[2,3-d] pyrimidines; Next generation irreversible EGFR_T790M inhibitors
Zhou, Ru
Behenna, Douglas
Cho-Schultz, Sujin
Kath, John
Kephart, Susan
Liu, Kevin
Matthews, Jean
Nair, Sajiv
Ornelas, Martha
Orr, Suvi
Pairish, Mason
Richter, Daniel
Sach, Neal
Shen, Hong
Sutton, Scott
Tao, Yong
Khanh Tran
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2015, 250
[3] Discovery of 7H-pyrrolo[2,3-d]pyrimidine derivatives as selective covalent irreversible inhibitors of interleukin-2-inducible T-cell kinase (Itk)
Tang, Guanghui
Liu, Lihong
Wang, Xueying
Pan, Zhengying
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 173 : 167 - 183
[4] SYNTHESIS OF 7-UNSUBSTITUTED 7H-PYRROLO[2,3-D]PYRIMIDINES
PICHLER, H
FOLKERS, G
ROTH, HJ
EGER, K
LIEBIGS ANNALEN DER CHEMIE, 1986, (09): : 1485 - 1505
[5] Development of novel nitric oxide production inhibitors based on the 7H-pyrrolo[2,3-d]pyrimidine scaffold
Zhang, Jie
Xie, Xin
Qin, Tingsheng
Yao, Hualiang
Ling, Zhen
Deng, Fengyuan
Yue, Xiaoyang
He, Linhong
MOLECULAR DIVERSITY, 2025, 29 (01) : 457 - 469
[6] Design, synthesis, and biological evaluation of pyrido[2,3-d]pyrimidine and thieno[2,3-d]pyrimidine derivatives as novel EGFRL858R/T790M inhibitors
Fu, Jianfang
Yu, Jie
Zhang, Xiang
Chang, Yaoyao
Fan, Hongze
Dong, Mengzhen
Li, Mengjia
Liu, Yue
Hu, Jinxing
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2023, 38 (01)
[7] SYNTHESIS OF 2'-DEOXYRIBOFURANOSIDES OF 7H-PYRROLO[2,3-D]PYRIMIDINE - INFLUENCE OF THE C-2 SUBSTITUENTS ON THE FLUORESCENCE
SEELA, F
STEKER, H
LIEBIGS ANNALEN DER CHEMIE, 1984, (10): : 1719 - 1730
[8] 4-AMINO-7-(RAC-2,3-DIHYDROXYPROPYL)-7H-PYRROLO[2,3-D]PYRIMIDINE - SYNTHESIS OF ACYCLOTUBERCIDIN
SEELA, F
KEHNE, A
LIEBIGS ANNALEN DER CHEMIE, 1982, (11): : 1940 - 1945
[9] Synthesis and SAR of substituted 7H-pyrrolo[2,3-d]pyrimidines as ACK1 inhibitors
Jiao, Xianyun
Kopecky, David J. David J.
Liu, JinQian
Wang, Zhulun
Cardozo, Mario
Farrelly, Ellyn
Jaen, Juan
Liu, JinSong
Sharma, Rajiv
Walker, Nigel
Wesche, Holger
Xiao, Shou-Hua
Kayser, Frank
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 241
[10] Synthesis of 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine and 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine
Hao, Baoyu
Chen, Xinzhi
Zhang, Weihan
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2010, 30 (06) : 918 - 922

← 1 2 3 4 5 →