T regulatory cell markers in oral squamous cell carcinoma: Relationship with survival and tumor aggressiveness

被引：22

作者：

Moreira, Geane ^{[1
]}

Fulgencio, Livia Bonfim ^{[1
]}

De Mendonca, Elismauro Francisco ^{[2
,3
]}

Leles, Claudio Rodrigues ^{[3
]}

Batista, Aline Carvalho ^{[3
]}

Da Silva, Tarcilia Aparecida ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Sch Dent, Dept Oral Surg & Pathol, BR-31270901 Belo Horizonte, MG, Brazil

[2] Assoc Canc Combat Goias, Araujo Jorge Hosp, Head & Neck Div, Goiania, Go, Brazil

[3] Univ Fed Goias, Sch Dent, Dept Oral Med Oral Pathol, Goiania, Go, Brazil

来源：

ONCOLOGY LETTERS | 2010年 / 1卷 / 01期

关键词：

squamous cell carcinoma; T regulatory cells; immune response; TRANSCRIPTION FACTOR FOXP3; PROGNOSTIC VALUE; CD4(+); HEAD; EXPRESSION; CANCER; BLOCKADE; GENE; AUTOIMMUNITY; LYMPHOCYTES;

D O I：

10.3892/ol_00000023

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor-infiltrating lymphocytes (TILs) are a heterogeneous cell family which plays an important role in tumor-associated immune response Of these, T regulatory (Treg) cells have also been shown to inhibit anti-tumor response We aimed to evaluate the expression of T regulatory cell markers (CD4, CD25, CTLA-4 and FoxP3) in samples of oral cavity squamous cell carcinoma (OCSCC) and hp SCC (LSCC) by immunohistochemistry The relationship of Treg markers with survival data and the proliferative index were also evaluated We observed similar numbers of CD4-, CD25- and FoxP3+ cells in OCSCC and LSCC On the other hand, numbers of CTLA 4+ cells were significantly lower in OCSCC than in LSCC OCSCC samples with high numbers of CD4 exhibited a high proliferative index, while samples with high CTLA-4 counts demonstrated a low tumoral proliferative index A log-rank test showed that patients with OCSCC that presented high counts of CD4 showed a significantly decreased survival compared with patients with low cell counts In contrast, high CD25+ cell counts were associated with increased survival Our results suggest an association of CD4 with poor prognosis, while CD25 expression is related with favorable prognosis These findings result from the heterogeneity of TIL subsets that display an antagonistic role in tumor immune cell response

引用

页码：127 / 132

页数：6

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