Antithrombotic Therapy in Elderly Patients with Acute Coronary Syndromes

被引：7

作者：

Bonanad, Clara ^{[1
,2
,3
]}

Esteve-Claramunt, Francisca ^{[4
]}

Garcia-Blas, Sergio ^{[1
,2
,5
]}

Ayesta, Ana ^{[6
]}

Diez-Villanueva, Pablo ^{[7
]}

Perez-Rivera, Jose-Angel ^{[8
]}

Ferreiro, Jose Luis ^{[5
,9
]}

Canoves, Joaquim ^{[1
,2
,3
]}

Lopez-Fornas, Francisco ^{[1
,2
,3
]}

Ariza Sole, Albert ^{[8
]}

Raposerias, Sergio ^{[10
]}

Vivas, David ^{[11
]}

Blanco, Regina ^{[12
]}

Bompart Berroteran, Daznia ^{[3
]}

Cordero, Alberto ^{[5
,13
]}

Nunez, Julio ^{[1
,2
,3
,5
]}

Facila, Lorenzo ^{[14
]}

Nunez-Gil, Ivan J. ^{[11
]}

Gorriz, Jose Luis ^{[2
,3
,15
]}

Bodi, Vicente ^{[1
,2
,3
,5
]}

Martinez-Selles, Manuel ^{[16
]}

Ruiz Nodar, Juan Miguel ^{[17
]}

Chorro, Francisco Javier ^{[1
,2
,3
,5
]}

机构：

[1] Clin Univ Hosp Valencia, Cardiol Dept, Valencia 46010, Spain

[2] INCLIVA Biomed Res Inst, Valencia 46010, Spain

[3] Univ Valencia, Dept Med, Valencia 46010, Spain

[4] European Univ Valencia, Fac Hlth Sci, Dept Nursing, Valencia 46010, Spain

[5] Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid 28029, Spain

[6] Cent Univ Hosp Asturias, Cardiol Dept, Oviedo 33011, Spain

[7] La Princesa Univ Hosp, Cardiol Dept, Madrid 28006, Spain

[8] Isabel I Univ, Univ Hosp Burgos, Cardiol Dept, Burgos 09003, Spain

[9] Bellvitge Univ Hosp, Cardiol Dept, Barcelona 08907, Spain

[10] Alvaro Cunqueiro Univ Hosp, Cardiol Dept, Vigo 36213, Spain

[11] Univ Complutense Madrid, San Carlos Univ Hosp, Cardiovasc Inst, Dept Med, Madrid 28040, Spain

[12] Quironsalud Hosp Valencia, Cardiol Dept, Valencia 46010, Spain

[13] San Juan Univ Hosp, Cardiol Dept, Alicante 00921, Spain

[14] Gen Univ Hosp Valencia, Cardiol Dept, Valencia 46014, Spain

[15] Clin Univ Hosp Valencia, Dept Nephrol, Valencia 46010, Spain

[16] Univ Complutense Madrid, Univ Europea, Hosp Univ Gregorio Maranon, Cardiol Dept, Madrid 28040, Spain

[17] Hosp Gen Univ Alicante, Inst Invest Sanitaria & Biomed Alicante ISABIAL, CIBER CV, Serv Cardiol, Alicante 03010, Spain

来源：

JOURNAL OF CLINICAL MEDICINE | 2022年 / 11卷 / 11期

关键词：

acute coronary syndrome; elderly; antiplatelet therapy; clopidogrel; prasugrel; ticagrelor; DUAL ANTIPLATELET THERAPY; NONVALVULAR ATRIAL-FIBRILLATION; PRECISE-DAPT SCORE; ORAL ANTICOAGULANTS; MYOCARDIAL-INFARCTION; PLATELET INHIBITION; STENT IMPLANTATION; OPEN-LABEL; CLOPIDOGREL; TICAGRELOR;

D O I：

10.3390/jcm11113008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The treatment of acute coronary syndrome (ACS) in elderly patients continues to be a challenge because of the characteS.G.B.ristics of this population and the lack of data and specific recommendations. This review summarizes the current evidence about critical points of oral antithrombotic therapy in elderly patients. To this end, we discuss the peculiarities and differences reported referring to dual antiplatelet therapy (DAPT) in ACS management in elderly patients and what might be the best option considering these population characteristics. Furthermore, we analyze antithrombotic strategies in patients with atrial fibrillation (AF), with a particular focus on those cases that also present coronary artery disease (CAD). It is imperative to deepen our knowledge regarding the management of these challenging patients through real-world data and specifically designed geriatric studies to help resolve the questions remaining in their disease management.

引用

页数：15

共 74 条

[1] Comorbidity and low use of new antiplatelets in acute coronary syndrome [J].

Aboal, Jaime ;

Llao, Isaac ;

Garcia Garcia, Cosme ;

Sans-Rosello, Jordi ;

Sambola, Antonia ;

Andrea, Rut ;

Tomas, Carlos ;

Bonet, Gil ;

Ariza-Sole, Albert ;

Vinas, David ;

Oliveras Vila, Teresa ;

Montero, Santiago ;

Cantalapiedra, Javier ;

Pujol-Lopez, Margarida ;

Hernandez, Isabel ;

Perez-Rodriguez, Maria ;

Loma-Osorio, Pablo ;

Sanchez-Salado, Jose Carlos .

AGING CLINICAL AND EXPERIMENTAL RESEARCH, 2020, 32 (08) :1525-1531

[2] Comparative Safety and Effectiveness of Direct-Acting Oral Anticoagulants Versus Warfarin: a National Cohort Study of Nursing Home Residents [J].

Alcusky, Matthew ;

Tjia, Jennifer ;

McManus, David D. ;

Hume, Anne L. ;

Fisher, Marc ;

Lapane, Kate L. .

JOURNAL OF GENERAL INTERNAL MEDICINE, 2020, 35 (08) :2329-2337

[3] Effectiveness and safety of oral anticoagulants in older adults with non-valvular atrial fibrillation and heart failure [J].

Amin, Alpesh ;

Reeves, Alessandra B. Garcia ;

Li, Xiaoyan ;

Dhamane, Amol ;

Luo, Xuemei ;

Di Fusco, Manuela ;

Nadkarni, Anagha ;

Friend, Keith ;

Rosenblatt, Lisa ;

Mardekian, Jack ;

Pan, Xianying ;

Yuce, Huseyin ;

Keshishian, Allison .

PLOS ONE, 2019, 14 (03)

[4] Antithrombotic therapy in the elderly: expert position paper of the European Society of Cardiology Working Group on Thrombosis [J].

Andreotti, Felicita ;

Rocca, Bianca ;

Husted, Steen ;

Ajjan, Ramzi A. ;

ten Berg, Jurrien ;

Cattaneo, Marco ;

Collet, Jean-Philippe ;

De Caterina, Raffaele ;

Fox, Keith A. A. ;

Halvorsen, Sigrun ;

Huber, Kurt ;

Hylek, Elaine M. ;

Lip, Gregory Y. H. ;

Montalescot, Gilles ;

Morais, Joao ;

Patrono, Carlo ;

Verheugt, Freek W. A. ;

Wallentin, Lars ;

Weiss, Thomas W. ;

Storey, Robert F. .

EUROPEAN HEART JOURNAL, 2015, 36 (46) :3238-+

[5] Appropriateness of prescription of oral anticoagulant therapy in acutely hospitalized older people with atrial fibrillation. Secondary analysis of the SIM-AF cluster randomized clinical trial [J].

Antoniazzi, Stefania ;

Ardoino, Ilaria ;

Proietti, Marco ;

Monzani, Valter ;

Mannucci, Pier Mannuccio ;

Nobili, Alessandro ;

Franchi, Carlotta ;

Santalucia, Paola ;

Marcucci, Maura ;

Bosari, Silvano ;

Brignolo, Barbara ;

Nicolis, Enrico ;

Fenoglio, Luigi M. ;

Melchio, Remo ;

Fabris, Fabrizio ;

Sartori, Maria Teresa ;

Manfredini, Roberto ;

De Giorgi, Alfredo ;

Fabbian, Fabio ;

Biolo, Gianni ;

Zanetti, Michela ;

Altamura, Nicola ;

Sabba, Carlo ;

Suppressa, Patrizia ;

Bandiera, Francesco ;

Usai, Carlo ;

Murialdo, Giovanni ;

Fezza, Francesca ;

Marra, Alessio ;

Castelli, Francesca ;

Cattaneo, Federico ;

Beccati, Valentina ;

di Minno, Giovanni ;

Tufano, Antonella ;

Contaldi, Paola ;

Lupattelli, Graziana ;

Bianconi, Vanessa ;

Cappellini, Domenica ;

Hu, Cinzia ;

Minonzio, Francesca ;

Fargion, Silvia ;

Burdick, Larry ;

Francione, Paolo ;

Peyvandi, Flora ;

Rossio, Raffaella ;

Colombo, Giulia ;

Ceriani, Giuliana ;

Lucchi, Tiziano ;

Manfellotto, Dario ;

Caridi, Irene .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2019, 85 (09) :2134-2142

[6] Clinical Characteristics and Prognosis of Very Elderly Patients With Acute Coronary Syndrome Treated With Ticagrelor: Insights From the LONGEVO-SCA Registry [J].

Ariza-Sole, Albert ;

Formiga, Francesc ;

Bardaji, Alfredo ;

Viana-Tejedor, Ana ;

Alegre, Oriol ;

de Frutos, Fernando .

REVISTA ESPANOLA DE CARDIOLOGIA, 2019, 72 (03) :262-265

[7] Temporal Trends in the Use of Antiplatelet Therapy in Patients With Acute Coronary Syndromes [J].

Asuncion Esteve-Pastor, Maria ;

Miguel Ruiz-Nodar, Juan ;

Orenes-Pinero, Esteban ;

Miguel Rivera-Caravaca, Jose ;

Quintana-Giner, Miriam ;

Veliz-Martinez, Andrea ;

Tello-Montoliu, Antonio ;

PerniasEscrig, Vicente ;

Sandin Rollan, Miriam ;

Vicente-Ibarra, Nuria ;

Jesus MaciasVillanego, Manuel ;

Candela Sanchez, Elena ;

Carrillo Aleman, Luna ;

Lozano, Teresa ;

Valdes, Mariano ;

Marin, Francisco .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, 2018, 23 (01) :57-65

[8] Ticagrelor or Clopidogrel After an Acute Coronary Syndrome in the Elderly: A Propensity Score Matching Analysis from 16,653 Patients Treated with PCI Included in Two Large Multinational Registries [J].

Bianco, Matteo ;

Careggio, Alessandro ;

Biole, Carlo Alberto ;

Quadri, Giorgio ;

Quiros, Alicia ;

Raposeiras-Roubin, Sergio ;

Abu-Assi, Emad ;

Kinnaird, Tim ;

Ariza-Sole, Albert ;

Liebetrau, Christoph ;

Manzano-Fernandez, Sergio ;

Boccuzzi, Giacomo ;

Henriques, Jose P. S. ;

Spirito, Amanda ;

Templin, Christian ;

Wilton, Stephen B. ;

Velicki, Lazar ;

Correia, Luis ;

Rognoni, Andrea ;

Ugo, Fabrizio ;

Nunez-Gil, Ivan ;

Fujii, Toshiharu ;

Durante, Alessandro ;

Song, Xiantao ;

Kawaji, Tetsuma ;

Alexopoulos, Dimitrios ;

Huczek, Zenon ;

Juanatey, Jose Ramon Gonzalez ;

Nie, Shao-Ping ;

Kawashiri, Masa-Aki ;

Morbiducci, Umberto ;

Dominguez-Rodriguez, Alberto ;

Destefanis, Paola ;

Luciano, Alessia ;

De Ferrari, Gaetano Maria ;

Varbella, Ferdinando ;

Montagna, Laura ;

D'Ascenzo, Fabrizio ;

Cerrato, Enrico .

CARDIOVASCULAR DRUGS AND THERAPY, 2021, 35 (06) :1171-1182

[9] Comparison of Midterm Outcomes Associated With Aspirin and Ticagrelor vs Aspirin Monotherapy After Coronary Artery Bypass Grafting for Acute Coronary Syndrome [J].

Bjorklund, Erik ;

Malm, Carl Johan ;

Nielsen, Susanne J. ;

Hansson, Emma C. ;

Tygesen, Hans ;

Romlin, Birgitta S. ;

Martinsson, Andreas ;

Omerovic, Elmir ;

Pivodic, Aldina ;

Jeppsson, Anders .

JAMA NETWORK OPEN, 2021, 4 (08)

[10] Long-Term Use of Ticagrelor in Patients with Prior Myocardial Infarction [J].

Bonaca, Marc P. ;

Bhatt, Deepak L. ;

Cohen, Marc ;

Steg, Philippe Gabriel ;

Storey, Robert F. ;

Jensen, Eva C. ;

Magnani, Giulia ;

Bansilal, Sameer ;

Fish, M. Polly ;

Im, Kyungah ;

Bengtsson, Olof ;

Ophuis, Ton Oude ;

Budaj, Andrzej ;

Theroux, Pierre ;

Ruda, Mikhail ;

Hamm, Christian ;

Goto, Shinya ;

Spinar, Jindrich ;

Nicolau, Jose Carlos ;

Kiss, Robert G. ;

Murphy, Sabina A. ;

Wiviott, Stephen D. ;

Held, Peter ;

Braunwald, Eugene ;

Sabatine, Marc S. ;

Morin, Suzanne ;

Dantzer, Emily ;

Acquilano, Dayle ;

McGuire, Rachael L. ;

Gannon, Joseph B. ;

Gershman, Elaine ;

Ahlbom, Ann Maxe ;

Boberg, Barbro ;

Abola, Maria Teresa ;

Ardissino, Diego ;

Aylward, Philip ;

Corbalan, Ramon ;

Dalby, Anthony ;

Diaz, Rafael ;

Hu, Dayi ;

Isaza, Daniel ;

Kamensky, Gabriel ;

Kiss, Robert ;

Kontny, Frederic ;

Lopez-Sendon, Jose ;

Medina, Felix ;

Montalescot, Gilles ;

Nicolau, Jose ;

Paolasso, Ernesto ;

Parkhomenko, Alexander .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (19) :1791-1800

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