Stereoarrayed CF3-Substituted 1,3-Diols by Dynamic Kinetic Resolution: Ruthenium(II)-Catalyzed Asymmetric Transfer Hydrogenation

被引：76

作者：

Cotman, Andrej Emanuel ^{[1
,2
]}

Cahard, Dominique ^{[3
]}

Mohar, Barbara ^{[1
]}

机构：

[1] Natl Inst Chem, Hajdrihova 19, Ljubljana 1000, Slovenia

[2] Univ Ljubljana, Fac Chem & Chem Technol, Ljubljana 61000, Slovenia

[3] Univ & INSA Rouen, UMR CNRS COBRA 6014, 1 Rue Tesniere, F-76821 Mont St Aignan, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 17期

关键词：

alcohols; asymmetric catalysis; enantioselectivity; kinetic resolution; ruthenium; ANSA-RUTHENIUM(II) COMPLEXES; ENANTIOSELECTIVE SYNTHESIS; CONJUGATE LIGANDS; CATALYSTS; KETONES; BONDS;

D O I：

10.1002/anie.201600812

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

CF3-substituted 1,3-diols were stereoselectively prepared in excellent enantiopurity and high yield from CF3-substituted diketones by using an ansa-ruthenium(II)-catalyzed asymmetric transfer hydrogenation in formic acid/triethylamine. The intermediate mono-reduced alcohol was also obtained in very high enantiopurity by applying milder reaction conditions. In particular, CF3C(O)-substituted benzofused cyclic ketones underwent either a single or a double dynamic kinetic resolution during their reduction.

引用

页码：5294 / 5298

页数：5

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